Adamczyk Agnieszka, Niemiec Joanna, Ambicka Aleksandra, Mucha-Małecka Anna, Ryś Janusz, Mituś Jerzy, Wysocki Wojciech M, Cichocka Anna, Jakubowicz Jerzy
Department of Applied Radiobiology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland.
Department of Tumor Pathology, Maria Sklodowska-Curie Memorial Cancer Centre & Institute of Oncology, Cracow Branch, 31-115 Cracow, Garncarska 11, Poland.
Biomark Med. 2016;10(3):219-28. doi: 10.2217/bmm.15.123. Epub 2016 Feb 10.
The differences between primary and metastatic tumor cells might be important for treatment selection and prognostication.
MATERIALS & METHODS: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in primary tumor (T) and corresponding synchronous nodal metastases (LNM) in 156 invasive ductal breast cancer patients (T ≥1, N ≥1, M0).
Independent negative prognostic factors for disease-free survival were pN3, ALDH immunopositivity in LNM, nonluminal A subtype in LNM, reduction of Ep-CAM expression in LNM, lack of changes or enhancement of CK5/6 and ALDH expression in LNM.
Our results suggest that in some cases expression of markers in lymph node metastases might bring additional prognostic information to that obtained from primary tumor.
原发性肿瘤细胞和转移性肿瘤细胞之间的差异对于治疗选择和预后判断可能具有重要意义。
采用免疫组织化学方法评估了156例浸润性导管癌患者（T≥1，N≥1，M0）原发性肿瘤（T）及相应的同步淋巴结转移灶（LNM）中雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）、细胞角蛋白5/6（CK5/6）、表皮生长因子受体（EGFR）、Ki-67、上皮细胞黏附分子（Ep-CAM）、P-钙黏蛋白、CD24、CD44、乙醛脱氢酶（ALDH）的表达情况。
无病生存的独立阴性预后因素为pN3、LNM中ALDH免疫阳性、LNM中非腔面A型亚型、LNM中Ep-CAM表达降低、LNM中CK5/6和ALDH表达无变化或升高。
我们的结果表明，在某些情况下，淋巴结转移灶中标志物的表达可能会为从原发性肿瘤获得的预后信息带来额外补充。
