磷脂酰肌醇3,5-二磷酸：细胞事件在空间和时间上的调控
Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.
作者信息
Jin Natsuko, Lang Michael J, Weisman Lois S
机构信息
Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A.
出版信息
Biochem Soc Trans. 2016 Feb;44(1):177-84. doi: 10.1042/BST20150174.
Abstract
Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. The low-abundance signalling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is critical for cellular homoeostasis and adaptation to stimuli. A large complex of proteins that includes the lipid kinase Fab1-PIKfyve, dynamically regulates the levels of PI(3,5)P2. Deficiencies in PI(3,5)P2 are linked to some human diseases, especially those of the nervous system. Future studies will probably determine new, undiscovered regulatory roles of PI(3,5)P2, as well as uncover mechanistic insights into how PI(3,5)P2 contributes to normal human physiology.
摘要
磷酸化磷脂酰肌醇脂质对大多数真核生物至关重要，并具有多种细胞功能。低丰度信号脂质磷脂酰肌醇3,5-二磷酸[PI(3,5)P2]对细胞稳态和对刺激的适应性至关重要。一个包含脂质激酶Fab1-PIKfyve的大型蛋白质复合物动态调节PI(3,5)P2的水平。PI(3,5)P2的缺乏与一些人类疾病有关，尤其是神经系统疾病。未来的研究可能会确定PI(3,5)P2新的、未被发现的调节作用，以及揭示PI(3,5)P2如何促进正常人体生理功能的机制性见解。
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