新生雌性通过PI(3,5)P2介导的液泡酸化获得新的开始。
Newborn daughters get a fresh start through PI(3,5)P2-mediated vacuolar acidification.
作者信息
Kane Patricia M
机构信息
Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY, USA.
出版信息
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202412054. Epub 2024 Dec 20.
Abstract
Huda et al. (https://doi.org/10.1083/jcb.202406170) reveal a transient, cell cycle-dependent increase in PI(3,5)P2 levels at the lysosome-like vacuole of yeast daughter cells. The resulting lipid asymmetry alters vacuolar pH in both daughter and mother cells and will impact multiple downstream functions.
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本文引用的文献
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J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202406170. Epub 2024 Nov 8.
2
The signalling lipid PI3,5P is essential for timely mitotic exit.信号脂质 PI3,5P 对于适时的有丝分裂退出是必不可少的。
Open Biol. 2023 Sep;13(9):230125. doi: 10.1098/rsob.230125. Epub 2023 Sep 27.
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Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth.细胞周期相关的液泡 pH 动态调节氨基酸稳态和细胞生长。
Nat Metab. 2023 Oct;5(10):1803-1819. doi: 10.1038/s42255-023-00872-1. Epub 2023 Aug 28.
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Autophagic and non-autophagic functions of the PROPPINs Atg18, Atg21 and Hsv2.PROPPINs Atg18、Atg21 和 Hsv2 的自噬和非自噬功能。
Biol Chem. 2023 May 5;404(8-9):813-819. doi: 10.1515/hsz-2023-0126. Print 2023 Jul 26.
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Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.磷脂酰肌醇3,5-二磷酸：细胞事件在空间和时间上的调控
Biochem Soc Trans. 2016 Feb;44(1):177-84. doi: 10.1042/BST20150174.
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The vacuole/lysosome is required for cell-cycle progression.细胞周期进程需要液泡/溶酶体。
Elife. 2015 Aug 31;4:e08160. doi: 10.7554/eLife.08160.
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Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.自噬相关蛋白18（Atg18）独立于磷脂酰肌醇3,5-二磷酸介导的膜募集作用，调控细胞器形态及Fab1激酶活性。
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