磷脂酰肌醇5磷酸（PI5P）和磷脂酰肌醇-3,5-二磷酸（PI(3,5)P）：微量但必不可少的磷酸肌醇。
PI5P and PI(3,5)P: Minor, but Essential Phosphoinositides.
作者信息
Hasegawa Junya, Strunk Bethany S, Weisman Lois S
机构信息
Life Sciences Institute, University of Michigan.
出版信息
Cell Struct Funct. 2017 May 3;42(1):49-60. doi: 10.1247/csf.17003. Epub 2017 Mar 7.
Abstract
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial for the endocytic pathway, intracellular signaling, and adaptation to stress. Mutations that causes defects in the biosynthesis of PI5P and PI(3,5)P are linked to human diseases including neurodegenerative disorders. Here, we review recent findings on cellular roles of PI5P and PI(3,5)P, as well as the pathophysiological importance of these lipids.Key words: Phosphoinositides, Membrane trafficking, Endocytosis, Vacuoles/Lysosomes, Fab1/PIKfyve.
摘要
在大多数真核生物中，磷酸肌醇（PIs）在多种细胞功能中发挥着关键作用。尽管相对于其他一些磷酸肌醇，磷脂酰肌醇5-磷酸（PI5P）和磷脂酰肌醇3,5-二磷酸（PI(3,5)P）的细胞水平极低，但新出现的证据表明，这两种脂质对于内吞途径、细胞内信号传导以及应激适应都至关重要。导致PI5P和PI(3,5)P生物合成缺陷的突变与包括神经退行性疾病在内的人类疾病有关。在这里，我们综述了关于PI5P和PI(3,5)P细胞作用的最新发现，以及这些脂质的病理生理重要性。关键词：磷酸肌醇、膜运输、内吞作用、液泡/溶酶体、Fab1/PIKfyve。
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