基于伊朗伊斯法罕地区性别差异的首次急性心肌梗死患者28天生存率的预后因素（2000 - 2009年）

Prognostic factors of 28 days survival rate in patients with a first acute myocardial infarction based on gender in Isfahan, Iran (2000-2009).

作者信息

Mohammadian Mahdi, Hosseini Shidokht, Salehiniya Hamid, Sadeghi Masoumeh, Sarrafzadegan Nizal, Roohafza Hamid Reza, Khazaei Salman, Soltani Shahin, Sarrafkia Ali, Golshahi Jafar, Mohammadian-Hafshejani Abdollah

机构信息

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Researcher, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

ARYA Atheroscler. 2015 Nov;11(6):332-40.

PMID:26862341

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4738043/

Abstract

BACKGROUND

Determinant prognostic factors of 28 days survival rate in patients with a first acute myocardial infarction (AMI) based on gender in teen year's period in Isfahan, Iran, was the aim of this study.

METHODS

This study is a prospective hospital-based study that consisted, all patients with AMI admitted to all hospitals (private and universal hospitals) in Isfahan and Najafabad (Iran) during 2000-2009. To determinant the prognostic factors of 28 days survival rate in patients based on gender, analysis conducted separately for male and female. In analysis, we use of t-test, log Rank tests, Kaplan-Meier method, and univariate and multivariate Cox regression model.

RESULTS

Short-term (28 days) survival rate was 92.5% in male and 86.7% in female (P < 0.001). The adjusted hazard ratio (HR) of death for age group 80 years and older was 12.7 [95% confidence interval (CI): 5.14-31.3] in male and 8.78 (95% CI: 1.2-63.1) in female. HR for acute transmural MI of the unspecified site in male was 8.9 (95% CI: 4.68-16.97) and in female 9.33 (95% CI: 4.42-19.7). HR for receive of streptokinase in male was 1.11 (95% CI: 0.94-1.31) and in female was 0.69 (95% CI: 0.56-0.84).

CONCLUSION

Short-term survival rate in male was a higher than female. In male age, anatomic location of MI and hospital status and in female streptokinase use and anatomic location of MI was the most important prognostic factors of survival in-patient with AMI in Isfahan.

摘要

背景

本研究旨在探讨伊朗伊斯法罕青少年时期首次急性心肌梗死（AMI）患者28天生存率的决定性预后因素，并基于性别进行分析。

方法

本研究是一项基于医院的前瞻性研究，纳入了2000年至2009年期间在伊斯法罕和纳贾法巴德（伊朗）所有医院（私立和综合医院）收治的所有AMI患者。为了确定基于性别的患者28天生存率的预后因素，分别对男性和女性进行分析。分析过程中，我们使用了t检验、对数秩检验、Kaplan-Meier方法以及单变量和多变量Cox回归模型。

结果

男性的短期（28天）生存率为92.5%，女性为86.7%（P<0.001）。80岁及以上年龄组男性的死亡调整风险比（HR）为12.7[95%置信区间（CI）：5.14 - 31.3]，女性为8.78（95%CI：1.2 - 63.1）。男性未指定部位急性透壁性心肌梗死的HR为8.9（95%CI：4.68 - 16.97），女性为9.33（95%CI：4.42 - 19.7）。男性接受链激酶治疗的HR为1.11（95%CI：0.94 - 1.31），女性为0.69（95%CI：0.56 - 0.84）。