Department of Environmental and Occupational Medicine, Medical Academy, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT-50103 Kaunas, Lithuania.
Medicina (Kaunas). 2019 Jul 9;55(7):357. doi: 10.3390/medicina55070357.
: There is a lack of reliable epidemiological data on the long-term survival after acute myocardial infarction (AMI) in the Lithuanian population. The aim of the study was to evaluate the long-term (36 months) survival after AMI among persons aged 25-64 years, who had experienced AMI in four time-periods 1996, 2003-2004, 2008, and 2012. : The source of the data was Kaunas population-based Ischemic heart disease (IHD) register. Long-term survival after AMI (36 months) was evaluated using the Kaplan-Meier method. The survival curves significantly differed when < 0.05. Hazard ratio for all-cause mortality and their 95% CIs, adjusted for baseline characteristics, were estimated with the Cox proportional hazards regression model. The analysis of data on 36 months long-term survival among Kaunas population by sex and age groups showed that the survival rates among men and women were 83.4% and 87.6%, respectively ( < 0.05) and among 25-54 years-old and 55-64 years-old persons, 89.2% and 81.7%, respectively ( < 0.05). The rates of long-term survival of post-AMI Kaunas population were better in past periods than in first period. According to the data of the Kaplan-Meier survival analysis, long-term survival of 25 to 64-year-old post-AMI Kaunas population was without significantly difference in 1996, 2003-2004, 2008 and 2012 (Log-rank = 6.736, = 0.081). The adjusted risk of all-cause mortality during 36 months among men and 25 to 54-year-old patients was on the average by 35% and 60% lower in 2012 than in 1996, respectively. : It was found that 36 months survival post MI among women and younger (25-54 years) persons was significant better compared to men and older (55-64 years) persons. Long-term survival among 55 to 64-year-old post-AMI Kaunas population had a tendency to decrease during last period, while among 25-54 years old persons long-term survival was without significant changes. The results highlight the fact that AMI survivors, especially in youngest age, remain a high-risk group and reinforce the importance of primary and secondary prevention for the improvement of long-term prognosis of AMI patients.
在立陶宛人群中，急性心肌梗死（AMI）后长期生存的可靠流行病学数据缺乏。本研究的目的是评估四个时间段（1996 年、2003-2004 年、2008 年和 2012 年）发生 AMI 的 25-64 岁人群的 36 个月长期生存情况。数据来源为考纳斯人群为基础的缺血性心脏病（IHD）登记处。使用 Kaplan-Meier 方法评估 AMI 后 36 个月的长期生存情况。当 < 0.05 时，生存曲线差异具有统计学意义。使用 Cox 比例风险回归模型估计全因死亡率的风险比及其 95%置信区间，并根据基线特征进行调整。对考纳斯人群 36 个月长期生存的性别和年龄组数据进行分析，结果显示男性和女性的生存率分别为 83.4%和 87.6%（< 0.05），25-54 岁和 55-64 岁人群的生存率分别为 89.2%和 81.7%（< 0.05）。与第一时间段相比，过去时间段 AMI 后考纳斯人群的长期生存率更好。根据 Kaplan-Meier 生存分析数据，25-64 岁 AMI 后考纳斯人群的长期生存在 1996 年、2003-2004 年、2008 年和 2012 年之间无显著差异（Log-rank = 6.736，= 0.081）。2012 年男性和 25-54 岁患者在 36 个月期间全因死亡率的调整风险分别比 1996 年平均降低 35%和 60%。结果表明，与男性和老年（55-64 岁）患者相比，女性和年轻（25-54 岁）患者的 MI 后 36 个月生存率显著更好。在最后一个时期，55-64 岁 AMI 后考纳斯人群的长期生存率呈下降趋势，而 25-54 岁人群的长期生存率无显著变化。研究结果强调了 AMI 幸存者，尤其是最年轻的幸存者仍然是一个高风险群体的事实，并强调了初级和二级预防对于改善 AMI 患者长期预后的重要性。
