Damm P, Mølsted-Pedersen L
Department of Obstetrics and Gynaecology Y, Rigshospitalet, University of Copenhagen, Denmark.
Am J Obstet Gynecol. 1989 Nov;161(5):1163-7. doi: 10.1016/0002-9378(89)90656-x.
In an unselected and consecutive series of 1858 newborn infants of diabetic mothers, born in the Rigshospital, Copenhagen, in the period 1967 to 1986, congenital malformations were studied. The malformation rate in White Classes B to F was remarkably constant from 1967 to 1981, but a significant decrease in major congenital malformations was found in the period 1982 to 1986 versus 1977 to 1981 (2.7% vs. 7.4%, p less than 0.05). This decrease was mainly due to a fourfold decline in major congenital malformations in White Classes D and F (p less than 0.01), and consequently a correlation between the severity of maternal diabetes and the frequency of congenital malformations was no longer present. In the offspring of a control group of 1715 nondiabetic women, major congenital malformations were found in 1.7% (p greater than 0.05). Seventy-five percent of the diabetic pregnancies were planned, and in these pregnancies only 1% of the infants had major congenital malformations. The frequency of fatal malformations in White Classes B to F was still significantly higher than in the control group (p less than 0.001).
在1967年至1986年期间于哥本哈根里格医院出生的1858例患有糖尿病母亲的新生儿的非选择性连续系列中，对先天性畸形进行了研究。1967年至1981年期间，B至F级白人的畸形率相当稳定，但1982年至1986年期间与1977年至1981年相比，主要先天性畸形显著减少（2.7%对7.4%，p小于0.05）。这种减少主要是由于D级和F级白人的主要先天性畸形下降了四倍（p小于0.01），因此，母亲糖尿病的严重程度与先天性畸形的发生率之间不再存在相关性。在1715名非糖尿病女性对照组的后代中，发现主要先天性畸形的比例为1.7%（p大于0.05）。75%的糖尿病妊娠是计划内的，在这些妊娠中，只有1%的婴儿患有主要先天性畸形。B至F级白人中致命畸形的发生率仍显著高于对照组（p小于0.001）。
