Kawasaki Katsushige, Kawasaki Maiko, Watanabe Momoko, Idrus Erik, Nagai Takahiro, Oommen Shelly, Maeda Takeyasu, Hagiwara Nobuko, Que Jianwen, Sharpe Paul T, Ohazama Atsushi
Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Int J Dev Biol. 2015;59(10-12):471-8. doi: 10.1387/ijdb.150192ao.
Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.
Sox基因家族成员在包括器官发生在内的许多生物学过程中发挥作用。我们对17个sox基因（Sox1 - 14、17、18、21）在小鼠牙齿发生过程中从上皮增厚到细胞分化阶段进行了比较原位杂交分析。在牙胚上皮中观察到5个Sox基因（Sox6、9、13、14和21）的定位表达。Sox13在原发性釉结中表现出受限表达。在钟状早期阶段，3个Sox基因（Sox8、11、17和21）在成釉细胞前体细胞中表达，而另外2个（Sox5和18）在成牙本质细胞中表达。因此，Sox基因在牙齿发育过程中表现出动态的时空表达。
