Sox基因在小鼠腭发育过程中的时空表达。
Spatio-temporal expression of Sox genes in murine palatogenesis.
作者信息
Watanabe Momoko, Kawasaki Katsushige, Kawasaki Maiko, Portaveetus Thantrira, Oommen Shelly, Blackburn James, Nagai Takahiro, Kitamura Atsushi, Nishikawa Atsushi, Kodama Yasumitsu, Takagi Ritsuo, Maeda Takeyasu, Sharpe Paul T, Ohazama Atsushi
机构信息
Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK; Oral Life Science, Research Center for Advanced Oral Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
出版信息
Gene Expr Patterns. 2016 Jul;21(2):111-8. doi: 10.1016/j.gep.2016.05.002. Epub 2016 May 27.
Members of the Sox gene family play critical roles in many biological processes including organogenesis. We carried out comparative in situ hybridisation analysis of seventeen Sox genes (Sox1-14, 17, 18 and 21) during murine palatogenesis from initiation to fusion of the palatal shelves above the dorsal side of the tongue. At palatal shelf initiation (E12.5), the localized expression of six Sox genes (Sox2, 5, 6, 9, 12 and 13) was observed in the shelves, whereas Sox4 and Sox11 showed ubiquitious expression. During the down-growth of palatal shelves (E13.5), Sox4, Sox5, and Sox9 exhibited restricted expression to the interior side of the palatal shelves facing the tongue. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis.
Sox基因家族成员在包括器官发生在内的许多生物学过程中发挥着关键作用。我们对17个Sox基因（Sox1 - 14、17、18和21）在小鼠腭发育过程中从腭突起始到腭突在舌背上方融合的阶段进行了比较原位杂交分析。在腭突起始阶段（胚胎第12.5天，E12.5），在腭突中观察到6个Sox基因（Sox2、5、6、9、12和13）的局部表达，而Sox4和Sox11表现为广泛表达。在腭突向下生长阶段（E13.5），Sox4、Sox5和Sox9在面向舌的腭突内侧表现出受限表达。在腭突抬高后（E14.5），Sox2、Sox11和Sox21在中线上皮缝中表达。因此，我们确定了Sox基因家族在腭发育过程中的动态时空表达。
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