γ-氨基丁酸共同释放的机制与功能。
Mechanisms and functions of GABA co-release.
作者信息
Tritsch Nicolas X, Granger Adam J, Sabatini Bernardo L
机构信息
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
New York University Neuroscience Institute, Department of Neuroscience and Physiology, New York University Langone Medical Center, New York, New York 10016, USA.
出版信息
Nat Rev Neurosci. 2016 Mar;17(3):139-45. doi: 10.1038/nrn.2015.21. Epub 2016 Feb 11.
Abstract
The 'one neuron, one neurotransmitter' doctrine states that synaptic communication between two neurons occurs through the release of a single chemical transmitter. However, recent findings suggest that neurons that communicate using more than one classical neurotransmitter are prevalent throughout the adult mammalian CNS. In particular, several populations of neurons previously thought to release only glutamate, acetylcholine, dopamine or histamine also release the major inhibitory neurotransmitter GABA. Here, we review these findings and discuss the implications of GABA co-release for synaptic transmission and plasticity.
摘要
“一个神经元，一种神经递质”学说认为，两个神经元之间的突触通讯是通过释放单一化学递质来实现的。然而，最近的研究结果表明，在成年哺乳动物的中枢神经系统中，使用不止一种经典神经递质进行通讯的神经元很普遍。特别是，一些先前被认为只释放谷氨酸、乙酰胆碱、多巴胺或组胺的神经元群体，也会释放主要的抑制性神经递质γ-氨基丁酸（GABA）。在此，我们回顾这些研究结果，并讨论GABA共同释放对突触传递和可塑性的影响。
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