7-（苯并呋喃-2-基）-7-脱氮脱氧鸟苷作为单链DNA结合蛋白的荧光开启探针。
7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein.
作者信息
Tokugawa Munefumi, Masaki Yoshiaki, Canggadibrata Jan Christian, Kaneko Kazuhei, Shiozawa Takashi, Kanamori Takashi, Grøtli Morten, Wilhelmsson L Marcus, Sekine Mitsuo, Seio Kohji
机构信息
Department of Life Science, Tokyo Institute of Technology, J2-16, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan.
Department of Chemistry and Molecular Biology, University of Gothenburg, S-41296 Gothenburg, Sweden.
出版信息
Chem Commun (Camb). 2016 Mar 7;52(19):3809-12. doi: 10.1039/c5cc09700b.
7-(Benzofuran-2-yl)-7-deazadeoxyguanosine ((BF)dG) was synthesized and incorporated into an oligodeoxynucleotide (ODN). The single-stranded ODN containing (BF)dG shows 91-fold fluorescence enhancement upon binding of single-strand DNA binding protein.
7-（苯并呋喃-2-基）-7-脱氮脱氧鸟苷（（BF）dG）被合成并掺入到一个寡脱氧核苷酸（ODN）中。含有（BF）dG的单链ODN在与单链DNA结合蛋白结合后荧光增强了91倍。
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