通过富含蔗糖的半合成饮食在 Zucker “肥胖”（ff）大鼠中诱导出脂肪肝。

Proc Natl Acad Sci U S A. 1977 Jul;74(7):3038-42. doi: 10.1073/pnas.74.7.3038.

A new fatty liver model is described in which heredity plays a major role. A marked fatty liver develops when the homozygous mutant Zucker rat (ff or "fatty") is fed a semisynthetic diet enriched in sucrose. Lean littermates do not develop fatty liver on this experimental diet. Even old ff rats do not develop fatty livers on chow; the experimental diet is required. The fatty liver is described, including light microscopic and preliminary electron microscopic observations.

本文描述了一种新的脂肪肝模型，其中遗传因素起主要作用。当纯合突变型 Zucker 大鼠（ff 或“肥胖型”）喂食富含蔗糖的半合成饮食时，会出现明显的脂肪肝。同窝瘦鼠在这种实验饮食下不会发生脂肪肝。即使是老年 ff 大鼠在正常饮食下也不会发生脂肪肝；需要实验饮食。文中描述了脂肪肝，包括光学显微镜和初步电子显微镜观察结果。