莱姆病血清学检测的过去、现在及（可能的）未来
The Past, Present, and (Possible) Future of Serologic Testing for Lyme Disease.
作者信息
Theel Elitza S
机构信息
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
出版信息
J Clin Microbiol. 2016 May;54(5):1191-6. doi: 10.1128/JCM.03394-15. Epub 2016 Feb 10.
Abstract
Lyme disease prevails as the most commonly transmitted tick-borne infection in the United States, and serologic evaluation for antibodies to Borrelia burgdorferi remains the recommended modality for diagnosis. This review presents a brief historical perspective on the evolution of serologic assays for Lyme disease and provides a summary of the performance characteristics for the currently recommended two-tiered testing algorithm (TTTA). Additionally, a recently proposed alternative to the traditional TTTA is discussed, and novel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.
摘要
莱姆病是美国最常见的蜱传感染疾病，针对伯氏疏螺旋体抗体的血清学评估仍然是推荐的诊断方法。本综述简要介绍了莱姆病血清学检测方法的演变历史，并总结了当前推荐的两层检测算法（TTTA）的性能特征。此外，还讨论了最近提出的传统TTTA替代方法，并概述了包括免疫PCR和莱姆病代谢谱分析在内的新方法。
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