O'Connor Christine M, Nukui Masatoshi, Gurova Katerina V, Murphy Eain A
Department of Microbiology and Immunology, University at Buffalo-SUNY, Buffalo, New York, USA.
FORGE Life Science, LLC, Baruch S. Blumberg Research Institute, Doylestown, Pennsylvania, USA.
J Virol. 2016 Mar 28;90(8):4249-4253. doi: 10.1128/JVI.02501-15. Print 2016 Apr.
The successful colonization of the majority of the population by human cytomegalovirus is a direct result of the virus's ability to establish and, more specifically, reactivate from latency. The underlying cellular factors involved in viral reactivation remain unknown. Here, we show that the host complexfacilitateschromatintranscription (FACT) binds to the major immediate early promoter (MIEP) and that inhibition of this complex reduces MIEP transactivation, thus inhibiting viral reactivation.
人巨细胞病毒在大多数人群中的成功定植是该病毒建立潜伏并更具体地从潜伏状态重新激活能力的直接结果。参与病毒重新激活的潜在细胞因子仍然未知。在这里，我们表明宿主促进染色质转录（FACT）复合物与主要立即早期启动子（MIEP）结合，并且对该复合物的抑制会降低MIEP的反式激活，从而抑制病毒重新激活。
