Pénicaud L, Hitier Y, Ferré P, Girard J
Laboratoire de Physiologie du Dévelopement, Université Paris VII, L.A. 307 C.N.R.S., France.
Biochem J. 1989 Sep 15;262(3):881-5. doi: 10.1042/bj2620881.
The insulin-resistant obese fa/fa rat is a convenient model in which to study a potential effect of metformin, a biguanide used in the treatment of non-insulin-dependent diabetes, on insulin-mediated glucose utilization. Female fa/fa rats were given metformin orally for 8 days. Studies were performed on anaesthetized post-absorptive rats 5 h after the last dose of metformin. Glucose production and utilization were enhanced 1.5-fold in metformin-treated rats. The enhanced glucose production was almost entirely due to increased glucose recycling. The digestive tract was the only tissue responsible for the enhanced glucose utilization.
胰岛素抵抗的肥胖fa/fa大鼠是一种方便的模型,可用于研究二甲双胍(一种用于治疗非胰岛素依赖型糖尿病的双胍类药物)对胰岛素介导的葡萄糖利用的潜在影响。给雌性fa/fa大鼠口服二甲双胍8天。在末次给予二甲双胍5小时后,对麻醉后的空腹大鼠进行研究。二甲双胍治疗的大鼠的葡萄糖生成和利用增强了1.5倍。葡萄糖生成的增强几乎完全归因于葡萄糖再循环的增加。消化道是负责葡萄糖利用增强的唯一组织。