二甲双胍对遗传性肥胖（fa/fa）大鼠的降血糖作用源于肠道对血糖利用的增加。
Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine.
作者信息
Pénicaud L, Hitier Y, Ferré P, Girard J
机构信息
Laboratoire de Physiologie du Dévelopement, Université Paris VII, L.A. 307 C.N.R.S., France.
出版信息
Biochem J. 1989 Sep 15;262(3):881-5. doi: 10.1042/bj2620881.
Abstract
The insulin-resistant obese fa/fa rat is a convenient model in which to study a potential effect of metformin, a biguanide used in the treatment of non-insulin-dependent diabetes, on insulin-mediated glucose utilization. Female fa/fa rats were given metformin orally for 8 days. Studies were performed on anaesthetized post-absorptive rats 5 h after the last dose of metformin. Glucose production and utilization were enhanced 1.5-fold in metformin-treated rats. The enhanced glucose production was almost entirely due to increased glucose recycling. The digestive tract was the only tissue responsible for the enhanced glucose utilization.
摘要
胰岛素抵抗的肥胖fa/fa大鼠是一种方便的模型，可用于研究二甲双胍（一种用于治疗非胰岛素依赖型糖尿病的双胍类药物）对胰岛素介导的葡萄糖利用的潜在影响。给雌性fa/fa大鼠口服二甲双胍8天。在末次给予二甲双胍5小时后，对麻醉后的空腹大鼠进行研究。二甲双胍治疗的大鼠的葡萄糖生成和利用增强了1.5倍。葡萄糖生成的增强几乎完全归因于葡萄糖再循环的增加。消化道是负责葡萄糖利用增强的唯一组织。
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本文引用的文献
1
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
2
Tissue distribution of C14-labeled beta-phenethylbiguanide.C14标记的β-苯乙双胍的组织分布
Diabetes. 1960 May-Jun;9:163-6. doi: 10.2337/diab.9.3.163.
3
The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects.二甲双胍治疗对正常受试者胃酸分泌及胃肠激素水平的影响。
Diabetologia. 1980 Aug;19(2):93-6. doi: 10.1007/BF00421851.
4
Glucose turnover during pregnancy in anaesthetized post-absorptive rats.麻醉后处于吸收后状态的大鼠孕期的葡萄糖周转率。
Biochem J. 1981 May 15;196(2):633-6. doi: 10.1042/bj1960633.
5
alpha-Methylglucoside satisfies only Na+-dependent transport system of intestinal epithelium.α-甲基葡萄糖苷仅满足肠上皮细胞的钠离子依赖性转运系统。
Am J Physiol. 1981 Nov;241(5):C227-32. doi: 10.1152/ajpcell.1981.241.5.C227.
6
7
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.二甲双胍在四氧嘧啶糖尿病大鼠体内的处置及其药理作用。
J Pharmacobiodyn. 1983 Feb;6(2):71-87. doi: 10.1248/bpb1978.6.71.
8
Clinical diagnosis of hyperlipoproteinemia.高脂蛋白血症的临床诊断
Am J Med. 1983 May 23;74(5A):5-9.
9
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.肝脏和外周胰岛素抵抗：2型（非胰岛素依赖型）和1型（胰岛素依赖型）糖尿病的共同特征。
Diabetologia. 1982 Oct;23(4):313-9. doi: 10.1007/BF00253736.
10
Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro.二甲双胍对体外培养的人脂肪组织中胰岛素代谢效应的影响。
Diabete Metab. 1984 Dec;10(5):311-5.
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