Kearns David N, Silberberg Alan
Department of Psychology, American University, Washington, DC, USA.
Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):289-92. doi: 10.1097/FBP.0000000000000218.
The present experiment tested whether the elasticity of demand for self-administered cocaine in rats is dose-dependent. Subjects lever pressed for three different doses of intravenous cocaine - 0.11, 0.33, and 1.0 mg/kg/infusion - on a demand procedure where the number of lever presses required per infusion increased within a session. The main finding was that demand for the 0.11 mg/kg dose was more elastic than it was for the two larger doses. There was no difference in demand elasticity between the 0.33 and 1.0 mg/kg doses. These results parallel findings previously reported in monkeys. The present study also demonstrated that a within-session procedure can be used to generate reliable demand curves.
本实验测试了大鼠自我注射可卡因的需求弹性是否呈剂量依赖性。实验对象在一个需求程序中按压杠杆以获取三种不同剂量的静脉注射可卡因——0.11、0.33和1.0毫克/千克/输注——在该程序中，每次输注所需的杠杆按压次数在一个实验时段内会增加。主要发现是，0.11毫克/千克剂量的需求比另外两种较大剂量的需求更具弹性。0.33毫克/千克和1.0毫克/千克剂量之间的需求弹性没有差异。这些结果与先前在猴子身上报道的结果相似。本研究还表明，一个实验时段内的程序可用于生成可靠的需求曲线。
