尼古丁预先暴露对雄性大鼠可卡因和蔗糖需求的影响。
The effect of nicotine pre-exposure on demand for cocaine and sucrose in male rats.
作者信息
Schwartz Lindsay P, Kearns David N, Silberberg Alan
机构信息
Department of Psychology, American University, Washington, District of Columbia, USA.
出版信息
Behav Pharmacol. 2018 Jun;29(4):316-326. doi: 10.1097/FBP.0000000000000357.
The aim of the present study was to determine how nicotine pre-exposure affects the elasticity of demand for intravenous cocaine and for sucrose pellets in adult male rats. In Experiment 1, demand for cocaine was assessed in rats that had nicotine in their drinking water. Nicotine pre-exposure significantly decreased rats' willingness to defend cocaine consumption as the price (measured as the number of responses per cocaine infusion) increased compared with a control group with no nicotine pre-exposure. That is, nicotine increased the elasticity of demand for cocaine infusions. Experiment 2 repeated the first experiment, but with rats working for sucrose pellets instead of cocaine. Nicotine pre-exposure had no effect on the elasticity of demand for sucrose. This pattern of results suggests that nicotine pre-exposure can reduce the reinforcing effects of cocaine, but not sucrose, in adult male rats.
本研究的目的是确定预先接触尼古丁如何影响成年雄性大鼠对静脉注射可卡因和蔗糖颗粒的需求弹性。在实验1中，对饮用水中含有尼古丁的大鼠的可卡因需求进行了评估。与未预先接触尼古丁的对照组相比，预先接触尼古丁显著降低了大鼠在价格（以每次可卡因注射的反应次数衡量）增加时捍卫可卡因消费的意愿。也就是说，尼古丁增加了对可卡因注射的需求弹性。实验2重复了第一个实验，但让大鼠为蔗糖颗粒而不是可卡因工作。预先接触尼古丁对蔗糖的需求弹性没有影响。这种结果模式表明，预先接触尼古丁可以降低成年雄性大鼠中可卡因的强化作用，但不能降低蔗糖的强化作用。
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