巴西南部南里奥格兰德州一场持续不到一个月的牛狂犬病疫情的分子流行病学追踪。
Molecular epidemiological tracing of a cattle rabies outbreak lasting less than a month in Rio Grande do Sul in southern Brazil.
作者信息
Itou Takuya, Fukayama Toshiharu, Mochizuki Nobuyuki, Kobayashi Yuki, Deberaldini Eduardo R, Carvalho Adolorata A B, Ito Fumio H, Sakai Takeo
机构信息
Nihon University Veterinary Research Center, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.
Department of Preventive Veterinary Medicine, Faculty of Agriculture and Veterinary Science, UNESP, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, Sao Paulo, 14884-900, Brazil.
出版信息
BMC Res Notes. 2016 Feb 12;9:87. doi: 10.1186/s13104-016-1898-5.
BACKGROUND
Vampire bat-transmitted cattle rabies cases are typically encountered in areas where the disease is endemic. However, over the period of a month in 2009, an outbreak of cattle rabies occurred and then ended spontaneously in a small area of the Rio Grande do Sul State in southern Brazil. To investigate the epidemiological characteristics of this rabies outbreak in Rio Grande do Sul, 26 nucleotide sequences of rabies virus (RABV) genomes that were collected in this area were analyzed phylogenetically.
RESULTS
Nucleotide sequence identities of the nucleoprotein gene and G-L intergenic region of the 26 RABVs were greater than 99.6 %. Phylogenetic analysis showed that all RABVs clustered with the vampire bat-related cattle RABV strains and that the RABVs were mainly distributed in southern Brazil.
CONCLUSIONS
The findings of the present study suggested that a small population of rabid vampire bats carrying a single RABV strain produced a spatiotemporally restricted outbreak of cattle rabies in southern Brazil.
背景
吸血蝙蝠传播的牛狂犬病病例通常在该病流行的地区出现。然而，在2009年的一个月时间里，巴西南部南里奥格兰德州的一个小区域爆发了牛狂犬病，随后疫情自行结束。为了调查南里奥格兰德州此次狂犬病疫情的流行病学特征，对该地区收集的26个狂犬病病毒（RABV）基因组的核苷酸序列进行了系统发育分析。
结果
26株狂犬病病毒核蛋白基因和G-L基因间隔区的核苷酸序列同一性大于99.6%。系统发育分析表明，所有狂犬病病毒均与吸血蝙蝠相关的牛狂犬病病毒株聚类，且这些狂犬病病毒主要分布在巴西南部。
结论
本研究结果表明，一小群携带单一狂犬病病毒株的狂犬病吸血蝙蝠在巴西南部引发了一场时空受限的牛狂犬病疫情。
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