Agrawal Rupesh, Gupta Preeti, Tan Kara-Anne, Cheung Chui Ming Gemmy, Wong Tien-Yin, Cheng Ching-Yu
Singapore Eye Research Institute and Singapore National Eye Center, Singapore.
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
Sci Rep. 2016 Feb 12;6:21090. doi: 10.1038/srep21090.
The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.
脉络膜的血管状态与多种眼部疾病的发病机制有关。迄今为止，尚无既定的可量化参数来评估脉络膜的血管状态。脉络膜血管指数（CVI）可能可用于评估脉络膜的血管状态。我们旨在建立CVI的正常数据库，并确定健康眼睛中与CVI相关的因素。在这项基于人群的对345只健康眼睛的研究中，采用改良的图像二值化技术对脉络膜增强深度成像光学相干断层扫描进行分割。将黄斑中心凹下脉络膜总面积（TCA）分割为管腔面积（LA）和基质面积（SA）。CVI计算为LA占TCA的比例。采用线性回归来确定与CVI及黄斑中心凹下脉络膜厚度（SFCT）相关的眼部和全身因素。黄斑中心凹下CVI范围为60.07%至71.27%，平均值为65.61±2.33%。CVI的变异性小于SFCT（CVI的变异系数为3.55，而SFCT为40.30）。较高的CVI与较厚的SFCT相关，但与大多数生理变量无关。CVI被阐明为SFCT的一个重要决定因素。虽然SFCT受多种因素影响，但CVI不受影响，这表明CVI是脉络膜疾病更可靠的标志物。
