Suksai Manaphat, Suwanrath Chitkasaem, Kor-anantakul Ounjai, Suntharasaj Thitima, Pruksanusak Ninlapa, Geater Alan
Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Int J Gynaecol Obstet. 2016 Apr;133(1):98-102. doi: 10.1016/j.ijgo.2015.09.021. Epub 2016 Jan 20.
To establish reference ranges for ductus venosus (DV) blood flow velocities and indices during the early second trimester.
A cross-sectional DV Doppler study of fetuses at 15-22 weeks of gestation was conducted at Songklanagarind Hospital, Songkhla, Thailand, during 2013-2014. The peak forward velocities were recorded and the DV indices were calculated. Predicted reference ranges based on the 5th and 95th percentiles according to the week of gestation were constructed.
Among 371 fetuses, measurement of DV Doppler waveforms in the sagittal plane was achieved in 97.5% of cases. With advancing pregnancy (weeks 15 to 22), the DV velocities during ventricular systole, early diastole, and atrial contraction increased from 47.48 cm/s to 68.22 cm/s, 42.23 cm/s to 60.52 cm/s, and 15.94 cm/s to 34.84 cm/s, respectively. The time-averaged maximum value increased from 37.61 cm/s to 55.42 cm/s. The DV indices-pulsatility index for the vein, peak velocity index for the vein, preload index, and systolic/a-wave ratio-decreased from 0.79 to 0.59, 0.71 to 0.53, 0.63 to 0.47, and 2.72 to 1.90, respectively. The systolic/diastolic ratio remained relatively constant at 1.12.
Normal reference ranges for DV flow velocities and indices during the early second trimester were established.
建立孕中期早期静脉导管（DV）血流速度和指数的参考范围。
2013年至2014年期间，在泰国宋卡的宋卡那加林医院对妊娠15 - 22周的胎儿进行了DV多普勒横断面研究。记录正向峰值速度并计算DV指数。根据妊娠周数构建基于第5和第95百分位数的预测参考范围。
在371例胎儿中，97.5%的病例在矢状面成功测量了DV多普勒波形。随着孕周增加（15至22周），心室收缩期、舒张早期和心房收缩期的DV速度分别从47.48 cm/s增加到68.22 cm/s、42.23 cm/s增加到60.52 cm/s、15.94 cm/s增加到34.84 cm/s。时间平均最大值从37.61 cm/s增加到55.42 cm/s。DV指数——静脉搏动指数、静脉峰值速度指数、前负荷指数和收缩期/a波比值分别从0.79降至0.59、0.71降至0.53、0.63降至0.47和2.72降至1.90。收缩期/舒张期比值保持相对恒定，为1.12。
建立了孕中期早期DV血流速度和指数的正常参考范围。
