Rock Philippa L, Goodwin Guy M, Wulff Katharina, McTavish Sarah F B, Harmer Catherine J
The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
University Department of Psychiatry, University of Oxford, Oxford, UK
J Psychopharmacol. 2016 Mar;30(3):273-82. doi: 10.1177/0269881115626336. Epub 2016 Feb 11.
Quetiapine is an atypical antipsychotic that can stabilise mood from any index episode of bipolar disorder. This study investigated the effects of seven-day quetiapine administration on sleep, circadian rhythms and emotional processing in healthy volunteers.
Twenty healthy volunteers received 150 mg quetiapine XL for seven nights and 20 matched controls received placebo. Sleep-wake actigraphy was completed for one week both pre-dose and during drug treatment. On Day 8, participants completed emotional processing tasks.
Actigraphy revealed that quetiapine treatment increased sleep duration and efficiency, delayed final wake time and had a tendency to reduce within-day variability. There were no effects of quetiapine on subjective ratings of mood or energy. Quetiapine-treated participants showed diminished bias towards positive words and away from negative words during recognition memory. Quetiapine did not significantly affect facial expression recognition, emotional word categorisation, emotion-potentiated startle or emotional word/faces dot-probe vigilance reaction times.
These changes in sleep timing and circadian rhythmicity in healthy volunteers may be relevant to quetiapine's therapeutic actions. Effects on emotional processing did not emulate the effects of antidepressants. The effects of quetiapine on sleep and circadian rhythms in patients with bipolar disorder merit further investigation to elucidate its mechanisms of action.
喹硫平是一种非典型抗精神病药物，可稳定双相情感障碍任何发作期的情绪。本研究调查了健康志愿者连续七天服用喹硫平对睡眠、昼夜节律和情绪加工的影响。
20名健康志愿者连续七个晚上服用150毫克缓释喹硫平，20名匹配的对照者服用安慰剂。在给药前和药物治疗期间均进行了为期一周的睡眠-觉醒活动监测。在第8天，参与者完成情绪加工任务。
活动监测显示，喹硫平治疗增加了睡眠时间和效率，延迟了最终觉醒时间，并倾向于减少日内变异性。喹硫平对情绪或精力的主观评分没有影响。接受喹硫平治疗的参与者在识别记忆过程中对积极词汇的偏向和对消极词汇的回避有所减少。喹硫平对面部表情识别、情绪词汇分类、情绪增强惊吓或情绪词汇/面孔点探测警觉反应时间没有显著影响。
健康志愿者睡眠时相和昼夜节律的这些变化可能与喹硫平的治疗作用有关。对情绪加工的影响并未模拟抗抑郁药的作用。喹硫平对双相情感障碍患者睡眠和昼夜节律的影响值得进一步研究以阐明其作用机制。
