Saad S, Gomez-Pereira P, Hewett K, Horstman P, Patel J, Greenman J
Microbiology Unit, University of West of England, Bristol, UK.
J Breath Res. 2016 Feb 12;10(1):016013. doi: 10.1088/1752-7155/10/1/016013.
The objective of this clinical investigation was to test the effectiveness on breath odor of a newly designed sonic tongue brush (TongueCare+, TC). It consists of a soft silicone brush optimally designed based on the tongue's anatomy to remove bacterial biofilm from the tongue's complex surface, and it is coupled with a sonic power toothbrush handle. TC was used in combination with an antibacterial tongue spray (BreathRx, BRx) containing 0.09% cetylpyridinium chloride and 0.7% zinc gluconate. A total of 21 participants with oral malodor exceeding the threshold for recognition took part in this cross-over clinical investigation, which consisted of a single use of four treatment arms with one week washout period in between. The treatments consisted of: (1) TC + BRx, (2) TC + water, (3) BRx and (4) water. Malodor levels and bacterial density were monitored up to 6 h by organoleptic scoring and selective plating, respectively. The organoleptic score and bacterial density were significantly lower after using TC + BRx compared to all alternative treatments at all time points. A significant decrease in both parameters was detected after a single use of TC + BRx, from levels characteristic of high oral malodor, to barely noticeable levels after treatment and this was maintained up to 6 h. Moreover, we identified a significant positive correlation between bacterial density and organoleptic score, confirming that bacterial tongue biofilm is the root cause of oral malodor in these subjects. The results of this clinical investigation demonstrated that the combined treatment of a sonic tongue brush with the antibacterial tongue spray is able to deliver more than 6 h of fresh breath following a single use. The clinical investigation was registered at the ISRCTN registry under study identification number ISRCTN38199132.
这项临床研究的目的是测试一种新设计的声波舌刷（TongueCare+，TC）对口气异味的效果。它由一个根据舌头解剖结构优化设计的柔软硅胶刷组成，用于从舌头复杂的表面去除细菌生物膜，并与声波电动牙刷手柄相连。TC与一种含有0.09%西吡氯铵和0.7%葡萄糖酸锌的抗菌舌喷雾（BreathRx，BRx）联合使用。共有21名口气异味超过可识别阈值的参与者参加了这项交叉临床研究，该研究包括单次使用四个治疗组，每组之间有一周的洗脱期。治疗方案包括：（1）TC + BRx，（2）TC + 水，（3）BRx，（4）水。分别通过感官评分和选择性平板培养法监测异味水平和细菌密度，最长监测6小时。在所有时间点，与所有其他替代治疗相比，使用TC + BRx后，感官评分和细菌密度显著降低。单次使用TC + BRx后，这两个参数均显著下降，从高口气异味特征水平降至治疗后几乎难以察觉的水平，并维持长达6小时。此外，我们发现细菌密度与感官评分之间存在显著正相关，证实细菌舌生物膜是这些受试者口气异味的根本原因。这项临床研究的结果表明，声波舌刷与抗菌舌喷雾联合治疗单次使用后能够提供超过6小时的清新口气。该临床研究已在ISRCTN注册中心注册，研究识别号为ISRCTN38199132。
