• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

(2R,3S)-3-[(叔丁基亚磺酰基)氨基]-2-氟-3-苯基丙酸甲酯的晶体结构

Crystal structure of methyl (2R,3S)-3-[(tert-butyl-sulfin-yl)amino]-2-fluoro-3-phenyl-propano-ate.

作者信息

Zhao Zhiwei, Fan Wenqiang, Zhang Yixiang, Li Ya

机构信息

Department of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, People's Republic of China.

出版信息

Acta Crystallogr E Crystallogr Commun. 2015 Dec 16;71(Pt 12):o1055-6. doi: 10.1107/S2056989015023580. eCollection 2015 Dec 1.

DOI:10.1107/S2056989015023580
PMID:26870495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4719976/
Abstract

The title compound, C14H20FNO3S, contains two chiral carbon centres and the absolute configuration has been confirmed as (2R,3S). In the crystal, adjacent mol-ecules are linked by weak C-H⋯O hydrogen bonds, generating zigzag chains along the a-axis direction.

摘要

标题化合物C₁₄H₂₀FNO₃S含有两个手性碳中心，其绝对构型已确认为(2R,3S)。在晶体中，相邻分子通过弱C-H⋯O氢键相连，沿a轴方向形成锯齿链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/4719976/d53c5a2bdb3e/e-71-o1055-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/4719976/3bcce56602b9/e-71-o1055-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/4719976/d53c5a2bdb3e/e-71-o1055-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/4719976/3bcce56602b9/e-71-o1055-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/4719976/d53c5a2bdb3e/e-71-o1055-fig2.jpg

相似文献

1
Crystal structure of methyl (2R,3S)-3-[(tert-butyl-sulfin-yl)amino]-2-fluoro-3-phenyl-propano-ate.(2R,3S)-3-[(叔丁基亚磺酰基)氨基]-2-氟-3-苯基丙酸甲酯的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Dec 16;71(Pt 12):o1055-6. doi: 10.1107/S2056989015023580. eCollection 2015 Dec 1.
2
Crystal structures of three N-(aryl-sulfon-yl)-4-fluoro-benzamides.三种N-（芳基磺酰基）-4-氟苯甲酰胺的晶体结构
Acta Crystallogr E Crystallogr Commun. 2016 Mar 31;72(Pt 4):575-82. doi: 10.1107/S2056989016005089. eCollection 2016 Apr 1.
3
Different intra- and inter-molecular hydrogen-bonding patterns in (3,4a,8a)-2-[(2,3)-3-(2,5--benzamido)-2-(2,5--benzo-yloxy)-4-phenyl-butyl]---butyldeca-hydro-iso-quinoline-3-carboxamides ( = H or Cl): compounds with moderate aspartyl protease inhibition activity.
Acta Crystallogr E Crystallogr Commun. 2017 May 31;73(Pt 6):913-917. doi: 10.1107/S2056989017007800. eCollection 2017 Jun 1.
4
(2R,6S)-tert-Butyl 2-(benzhydryl-carbamo-yl)-6-methyl-morpholine-4-carboxyl-ate.(2R,6S)-叔丁基 2-(二苯甲基氨基甲酰基)-6-甲基吗啉-4-羧酸酯
Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1437. doi: 10.1107/S1600536811017764. Epub 2011 May 20.
5
Methyl 2-[(tert-but-oxy-carbon-yl)amino]-3-(3-methyl-2-sulfanyl-idene-2,3-dihydro-1H-imidazol-1-yl)propano-ate.2-[(叔丁氧羰基)氨基]-3-(3-甲基-2-硫亚基-2,3-二氢-1H-咪唑-1-基)丙酸甲酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3206. doi: 10.1107/S1600536812043486. Epub 2012 Oct 24.
6
(3S*,4S*,E)-tert-Butyl 3,4-dibromo-5-oxo-cyclo-oct-1-ene-carboxyl-ate.（3S*，4S*，E）-叔丁基 3,4-二溴-5-氧代-环辛-1-烯-羧酸酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o232. doi: 10.1107/S1600536811053852. Epub 2011 Dec 23.
7
Crystal structure of (1S,2R,4S)-1-[(morpholin-4-yl)meth-yl]-4-(prop-1-en-2-yl)cyclo-hexane-1,2-diol.(1S,2R,4S)-1-[(吗啉-4-基)甲基]-4-(1-丙烯-2-基)环己烷-1,2-二醇的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Jan 1;71(Pt 1):79-81. doi: 10.1107/S2056989014027169.
8
Crystal structure of dimethyl 3,3'-[(4-fluoro-phen-yl)methyl-ene]bis-(1H-indole-2-carboxyl-ate).3,3'-[(4-氟苯基)亚甲基]双(1H-吲哚-2-羧酸)二甲酯的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Sep 12;71(Pt 10):1140-2. doi: 10.1107/S205698901501628X. eCollection 2015 Oct 1.
9
Crystal structure of dimethyl 3,3'-[(3-fluoro-phenyl)methyl-ene]bis-(1H-indole-2-carboxyl-ate).3,3'-[(3-氟苯基)亚甲基]双-(1H-吲哚-2-羧酸二甲酯的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Nov 29;70(Pt 12):593-5. doi: 10.1107/S1600536814025756. eCollection 2014 Dec 1.
10
Crystal structure of Boc-(S)-ABOC-(S)-Ala-(S)-ABOC-(S)-Phe-OBn chloro-form monosolvate.Boc-(S)-ABOC-(S)-丙氨酸-(S)-ABOC-(S)-苯丙氨酸苄酯氯仿单溶剂合物的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Sep 17;71(Pt 10):1193-5. doi: 10.1107/S2056989015016941. eCollection 2015 Oct 1.

本文引用的文献

1
Diastereoselective Addition of Metal α-Fluoroenolates of Carboxylate Esters to N-tert-Butylsulfinyl Imines: Synthesis of α-Fluoro-β-amino Acids.羧酸酯的金属α-氟烯醇盐与N-叔丁基亚磺酰亚胺的非对映选择性加成反应：α-氟-β-氨基酸的合成
J Org Chem. 2015 Sep 4;80(17):8739-47. doi: 10.1021/acs.joc.5b01574. Epub 2015 Aug 20.
2
Fluorinated proteins: from design and synthesis to structure and stability.氟化蛋白：从设计和合成到结构和稳定性。
Acc Chem Res. 2014 Oct 21;47(10):2878-86. doi: 10.1021/ar500125m. Epub 2014 Jun 2.
3
Enantioselective synthesis of α-fluoro-β(3)-amino esters: synthesis of enantiopure, orthogonally protected α-fluoro-β(3)-lysine.
对映选择性合成 α-氟-β(3)-氨基酯：对映纯、正交保护的 α-氟-β(3)-赖氨酸的合成。
J Org Chem. 2010 Nov 5;75(21):7365-72. doi: 10.1021/jo101600c.
4
Enantioselective synthesis of alpha-fluorinated beta-amino acid derivatives by an asymmetric mannich reaction and selective deacylation/decarboxylation reactions.通过不对称曼尼希反应以及选择性脱酰基/脱羧反应对α-氟化β-氨基酸衍生物进行对映选择性合成。
Chemistry. 2010 Jan 18;16(3):779-82. doi: 10.1002/chem.200902830.
5
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
6
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
7
Helix propensity of highly fluorinated amino acids.高度氟化氨基酸的螺旋倾向。
J Am Chem Soc. 2006 Dec 13;128(49):15556-7. doi: 10.1021/ja0640445.
8
Self-association and membrane-binding behavior of melittins containing trifluoroleucine.
J Am Chem Soc. 2001 Aug 1;123(30):7407-13. doi: 10.1021/ja004351p.