Kapczinski Natalia S, Narvaez Joana C, Magalhães Pedro V, Bücker Joana, Peuker Ana C, Loredo Ana C, Troiano Federico, Czepielewski Letícia, Rosa Adriane, Fries Gabriel R, Gama Clarissa S
Laboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia - Medicina Translacional (INCT-TM), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
Programa de Pós-Graduação em Medicina: Psiquiatria, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Braz J Psychiatry. 2016 Jul-Sep;38(3):201-6. doi: 10.1590/1516-4446-2014-1558. Epub 2016 May 2.
Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression.
Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test.
In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p < 0.001).
Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.
双相情感障碍（BD）患者的抑郁症状与更差的预后相关。然而，关于中度和重度抑郁的BD患者不同功能领域的神经认知概况的数据却很少。我们的目的是评估一组双相抑郁患者的认知和整体功能。
共有100例双相抑郁患者（78%为女性）和70例对照者（64%为女性）的数据，两组按年龄和教育水平配对。通过一套神经心理测试评估认知功能。使用功能评估简短测试评估功能状况。
在患者中，重度抑郁与执行功能测量方面较差的认知表现相关。重度抑郁患者的整体功能比中度抑郁患者更差（z = 2.54，p = 0.011）。在重度抑郁患者中，较低的整体功能与工作记忆得分较低（r = -0.200，p = 0.010）以及执行功能得分较低相关（r = -0.210，p = 0.007；以及r = 0.293，p < 0.001）。
我们的研究结果表明，认知障碍和整体功能障碍与双相抑郁中抑郁症状的严重程度相关。对BD患者的抑郁症状进行强化治疗对于改善认知功能以及进而改善功能结局至关重要。
