Li Hui, Zeng Chao, Wei Jie, Yang Tuo, Gao Shu-Guang, Li Yu-Sheng, Luo Wei, Xiao Wen-Feng, Xiong Yi-Lin, Lei Guang-Hua
From the Department of Orthopaedics (HL, CZ, TY, S-GG, Y-SL, WL, W-FX, Y-LX, G-HL); Health Management Center (JW), Xiangya Hospital; and Department of Epidemiology and Health Statistics (JW), School of Public Health, Central South University, Changsha, Hunan Province, China.
Medicine (Baltimore). 2016 Feb;95(6):e2838. doi: 10.1097/MD.0000000000002838.
To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA).This study covered a total of 2855 subjects. The serum Ca concentration was detected by the Arsenazo III method. The radiographic OA of the knee was defined as changes equivalent to Kellgren-Lawrence grade 2 on 1 side at least. The serum Ca concentration was categorized into 4 quartiles, which are ≤2.27, 2.28-2.34, 2.35-2.41, and ≥2.42 mmol/L, respectively. The relationship between serum Ca and radiographic knee OA was examined using the multivariable logistic analysis after adjusting a series of potential confounding factors. For each quartile of the relationship between serum Ca concentration and radiographic knee OA, the OR with 95% CI was calculated, and the one with the lowest value was considered to be the reference.An inverse association existed between serum Ca concentration and radiographic OA of the knee in the multivariable model and the model where the factors of age, sex, and BMI were adjusted. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth quartiles of serum Ca concentration were 1.05 (95% CI: 0.83-1.31), 1.01 (95% CI: 0.80-1.27), and 0.79 (95% CI: 0.62-1.00), respectively, in comparison with the reference (first) quartile. A trend approaching to statistical significant (P = 0.06) was observed. Meanwhile, the relative odds of radiographic OA of the knee were decreased by 0.79 times in the fourth quartile in comparison with the reference.There is likely to be an inverse association between serum Ca concentration and radiographic OA of the knee.
研究血清钙(Ca)浓度与膝关节X线骨关节炎(OA)之间的关系。本研究共纳入2855名受试者。采用偶氮胂III法检测血清钙浓度。膝关节X线OA定义为至少一侧相当于Kellgren-Lawrence 2级的改变。血清钙浓度分为4个四分位数,分别为≤2.27、2.28 - 2.34、2.35 - 2.41和≥2.42 mmol/L。在调整一系列潜在混杂因素后,使用多变量逻辑分析研究血清钙与膝关节X线OA之间的关系。对于血清钙浓度与膝关节X线OA关系的每个四分位数,计算95%置信区间(CI)的比值比(OR),并将最低值的作为参考。在多变量模型以及调整年龄、性别和BMI因素的模型中,血清钙浓度与膝关节X线OA之间存在负相关。血清钙浓度第二、第三和第四四分位数中膝关节X线OA的多变量调整OR(95%CI)分别为1.05(95%CI:0.83 - 1.31)、1.01(95%CI:0.80 - 1.27)和0.79(95%CI:0.62 - 1.00),与参考(第一)四分位数相比。观察到一种接近统计学显著性的趋势(P = 0.06)。同时,与参考相比,第四四分位数中膝关节X线OA的相对比值降低了0.79倍。血清钙浓度与膝关节X线OA之间可能存在负相关。