Zeng Chao, Li Hui, Wei Jie, Yang Tuo, Deng Zhen-han, Yang Ye, Zhang Yi, Yang Tu-bao, Lei Guang-hua
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
PLoS One. 2015 May 26;10(5):e0127666. doi: 10.1371/journal.pone.0127666. eCollection 2015.
To examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.
A total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.
The relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28-1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17-0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11-1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28-0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14-0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.
The findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA.
LevelIII, cross-sectional study.
分别研究膳食镁（Mg）摄入量与膝关节X线骨关节炎（OA）、关节间隙变窄（JSN）和骨赘（OST）之间的横断面关联。
本研究共纳入1626名受试者。采用经过验证的半定量食物频率问卷评估膳食摄入量。膝关节X线OA定义为至少一条腿的Kellgren-Lawrence（K-L）分级为2级。根据国际骨关节炎研究学会（OARSI）图谱分别评估JSN和OST。应用多变量逻辑分析模型在调整潜在混杂因素后测试各种关联。
与最低五分位数相比，镁摄入量处于第三五分位数时，膝关节X线OA的相对比值降低0.53倍[比值比（OR）0.53，95%置信区间（CI）0.28 - 1.01]，第四五分位数降低0.40倍（OR 0.40，95% CI 0.17 - 0.94），第五五分位数降低0.34倍（OR 0.34，95% CI 0.11 - 1.00），趋势P值为0.111。与最低五分位数相比，镁摄入量处于第三五分位数时，JSN的相对比值降低0.49倍（OR 0.49，95% CI 0.28 - 0.88），第五五分位数降低0.37倍（OR 0.37，95% CI 0.14 - 0.98），趋势P值为0.088。膳食镁摄入量与OST的存在之间无显著关系。
这项横断面研究的结果表明，镁摄入量与膝关节X线OA和JSN呈负相关。它支持镁在预防膝关节OA中的潜在作用。
III级，横断面研究。
