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用于口腔颌面应用的可生物降解金属的研究现状：综述

Research status of biodegradable metals designed for oral and maxillofacial applications: A review.

作者信息

Xia Dandan, Yang Fan, Zheng Yufeng, Liu Yunsong, Zhou Yongsheng

机构信息

Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, National Medical Products Administration, Key Laboratory for Dental Materials, Research Center of Engineering and Technology for Digital Dentistry, Ministry of Health, Beijing, 100081, China.

出版信息

Bioact Mater. 2021 Apr 27;6(11):4186-4208. doi: 10.1016/j.bioactmat.2021.01.011. eCollection 2021 Nov.

DOI:10.1016/j.bioactmat.2021.01.011
PMID:33997502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8099919/
Abstract

The oral and maxillofacial regions have complex anatomical structures and different tissue types, which have vital health and aesthetic functions. Biodegradable metals (BMs) is a promising bioactive materials to treat oral and maxillofacial diseases. This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications. Mg-based BMs and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration (GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation. Fe-based BMs have a relatively low degradation rate and insoluble degradation products, which greatly limit their application and clinical translation. Furthermore, we proposed potential future research directions for BMs in the oral and maxillofacial regions, including 3D printed BM bone scaffolds, surface modification for BMs GBR membranes, and BMs containing hydrogels for cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken together, the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

摘要

口腔颌面部具有复杂的解剖结构和不同的组织类型，具有重要的健康和美学功能。可生物降解金属是治疗口腔颌面部疾病的一种很有前景的生物活性材料。本文综述了可生物降解金属在口腔颌面部应用的研究现状和未来研究方向。详细讨论了用于骨折固定系统和引导骨再生（GBR）膜的镁基和锌基可生物降解金属。锌基可生物降解金属降解速率适中，用于GBR膜时力学性能优异，具有很大的临床转化潜力。铁基可生物降解金属降解速率相对较低，降解产物不溶，这极大地限制了它们的应用和临床转化。此外，我们提出了可生物降解金属在口腔颌面部的潜在未来研究方向，包括3D打印的可生物降解金属骨支架、可生物降解金属GBR膜的表面改性，以及用于软骨再生、软组织再生和神经再生的含可生物降解金属水凝胶。综上所述，口腔颌面部可生物降解金属的发展所取得的进展为进一步的临床转化奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/2c69b1c35518/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/9d66c3e23ecb/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/d13c0ee93054/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/736a4f553359/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/79fc25916bad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/34fbefe0f738/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/fed0c36e100e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/0d5cfa031312/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/ad7677170995/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/2c69b1c35518/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/9d66c3e23ecb/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/d13c0ee93054/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/736a4f553359/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/79fc25916bad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/34fbefe0f738/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/fed0c36e100e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/0d5cfa031312/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/ad7677170995/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58ad/8099919/2c69b1c35518/gr8.jpg

相似文献

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Research status of biodegradable metals designed for oral and maxillofacial applications: A review.

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[2]
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[3]
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[4]
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[6]
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[8]
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[2]
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[3]
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J Mater Sci Mater Med. 2025-6-25

[4]
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J Oral Maxillofac Pathol. 2025

[5]
phosphorus-modified MgGe/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and and osteogenesis and osteointegration performance for biodegradable bone-implant applications.

Bioact Mater. 2024-10-11

[6]
Macrophage-related inflammatory responses to degradation products of biodegradable molybdenum implants.

Mater Today Bio. 2025-1-23

[7]
Effects of Nanoscale precipitates on mechanical properties, corrosion resistance, and biocompatibility in Zn-Mn alloy.

Sci Rep. 2025-2-14

[8]
The Effect of Post Heat Treatment on the Microstructure and Mechanical Properties of Cold-Sprayed Zn-6Cu Deposits.

Materials (Basel). 2024-12-13

[9]
Guided Bone Regeneration in the Posterior Mandible Using a Resorbable Metal Magnesium Membrane and Fixation Screws: A Case Report.

Case Rep Dent. 2024-12-13

[10]
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J Tissue Eng. 2024-12-12

本文引用的文献

[1]
Biocompatibility and Immune Response of a Newly Developed Volume-Stable Magnesium-Based Barrier Membrane in Combination with a PVD Coating for Guided Bone Regeneration (GBR).

Biomedicines. 2020-12-20

[2]
3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration.

ACS Biomater Sci Eng. 2018-2-12

[3]
Zinc: The Metal of Life.

Compr Rev Food Sci Food Saf. 2014-7

[4]
In vivo evaluation of bending strengths and degradation rates of different magnesium pin designs for oral stapler.

J Appl Biomater Funct Mater. 2020

[5]
Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application.

Bioact Mater. 2020-10-9

[6]
Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials.

Biomedicines. 2020-8-21

[7]
Doxycycline and Zinc Loaded Silica-Nanofibrous Polymers as Biomaterials for Bone Regeneration.

Polymers (Basel). 2020-5-25

[8]
Autologous tooth graft: a histological comparison between dentin mixed with xenograft and dentin alone grafts in socket preservation.

J Biol Regul Homeost Agents. 2019

[9]
Comparing maximal forces in resorbable poly-L-lactic acid and titanium plates for mandibular fracture fixation.

Heliyon. 2020-4-3

[10]
Multi-material additive manufacturing technologies for Ti-, Mg-, and Fe-based biomaterials for bone substitution.

Acta Biomater. 2020-6

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