Jansen R W, de Meijer P H, van Lier H J, Hoefnagels W H
Department of Geriatric Medicine, University Hospital Nijmegen, The Netherlands.
J Am Geriatr Soc. 1989 Dec;37(12):1135-9. doi: 10.1111/j.1532-5415.1989.tb06677.x.
Pretreatment with a somatostatin analogue, octreotide (SMS 201-995), prevents postprandial blood pressure reduction in the elderly. We hypothesized that this beneficial effect on blood pressure is caused by an octreotide-induced suppression of insulin secretion. We studied the effects of octreotide and insulin administration on the course of blood pressure after oral glucose loading in 10 healthy hypertensive old persons (mean age 73 +/- 3 years). Octreotide was given in a dose of 50 micrograms subcutaneously (sc) (time = -30 minutes). Insulin was given sc in a dose of 0.3 U/kg body weight (time = -10 minutes) and glucose was given orally in a dose of 75 g in 300 mL water (time = 0 minutes). Plasma insulin concentrations remained essentially unchanged after placebo and rose to a maximum level of 58 +/- 6 mU/L following insulin administration. The course of blood pressure was not different following glucose loading with high or low plasma insulin levels. These data indicate that the effects of octreotide on postprandial blood pressure reduction in the elderly are unrelated to the inhibition of insulin secretion.
用生长抑素类似物奥曲肽（SMS 201 - 995）进行预处理可防止老年人餐后血压降低。我们推测这种对血压的有益作用是由奥曲肽诱导的胰岛素分泌抑制所致。我们研究了奥曲肽和胰岛素给药对10名健康高血压老年人（平均年龄73±3岁）口服葡萄糖负荷后血压变化过程的影响。奥曲肽以50微克皮下注射给药（时间 = -30分钟）。胰岛素以0.3 U/千克体重皮下注射给药（时间 = -10分钟），葡萄糖以75克溶于300毫升水中口服给药（时间 = 0分钟）。安慰剂给药后血浆胰岛素浓度基本保持不变，胰岛素给药后升至最高水平58±6 mU/L。高或低血浆胰岛素水平下葡萄糖负荷后血压变化过程无差异。这些数据表明奥曲肽对老年人餐后血压降低的作用与胰岛素分泌抑制无关。
