Jansen R W, Lenders J W, Peeters T L, van Lier H J, Hoefnagels W H
Department of Medicine, University Hospital Nijmegen, The Netherlands.
J Hypertens Suppl. 1988 Dec;6(4):S669-72. doi: 10.1097/00004872-198812040-00210.
The mechanism of postprandial blood pressure reduction in the elderly is unknown but it has been suggested that insulin and/or vasoactive gut hormones play a role in this phenomenon. The increase in insulin and other gut hormones induced by the glucose loading can be blocked by a synthetic long-acting somatostatin analogue. SMS 201-995. We carried out a double-blind randomized study on the effects of SMS 201-995 on the responses of blood pressure, heart rate, insulin and plasma noradrenaline to oral glucose loading in normotensive and hypertensive elderly subjects. After placebo was administered, mean arterial pressure fell by 15 +/- 1 mmHg (P less than 0.001) in hypertensive elderly and by 7 +/- 2 mmHg (P less than 0.01) in normotensive elderly subjects. In contrast, when SMS 201-995 was administered, blood pressure remained essentially unchanged in both groups. These data indicate that treatment with SMS 201-995 might be of value in patients with symptomatic postprandial hypotension.
老年人餐后血压降低的机制尚不清楚，但有人提出胰岛素和/或血管活性肠激素在这一现象中起作用。葡萄糖负荷诱导的胰岛素和其他肠激素的增加可被一种合成的长效生长抑素类似物SMS 201-995阻断。我们对SMS 201-995在正常血压和高血压老年受试者中对口服葡萄糖负荷后血压、心率、胰岛素和血浆去甲肾上腺素反应的影响进行了一项双盲随机研究。给予安慰剂后，高血压老年受试者的平均动脉压下降了15±1 mmHg（P<0.001），正常血压老年受试者下降了7±2 mmHg（P<0.01）。相比之下，给予SMS 201-995时，两组血压基本保持不变。这些数据表明，SMS 201-995治疗对有症状的餐后低血压患者可能有价值。
