用促性腺激素治疗的患者排卵前血浆17β-雌二醇（E2）水平与受孕情况

Pre-ovulatory plasma levels of 17beta-oestradiol (E2) and conception in patients treated with gonadotrophins.

作者信息

Ferin J, Thomas K, De Hertogh R

出版信息

Acta Endocrinol Suppl (Copenh). 1977;214:33-42.

Abstract

Twenty-six patients seeking advice for sterility were given courses of treatment with HMG-HCG. Ovarian maturation was followed by daily evaluation of plasma 17beta-oestradiol concentrations. HCG was administered as soon as 17beta-oestradiol levels reached 250 pg/ml. In a first group of 7 amenorrheic patients with lack of oestrogen activity, a pregnancy rate of 71.4% and an ovulation rate of 91.7% were achieved. In a second group of 5 amenorrheic patients showing evidence of oestrogen activity, a pregnancy rate of 80.0% and an ovulation rate of 100% were obtained. In a third group of 14 oligomenorrheic patients, the pregnancy rate attained 71.4% and the ovulation rate 96.9%. The overall pregnancy rate was 73.0%. With this procedure of monitoring HMG-HCG treatment by means of plasma 17beta-oestradiol levels, the multiple pregnancy rate reached only 11.7% and only one case of mild ovarian hyperstimulation was observed. Pre-ovulatory and pre-conceptional 17beta-oestradiol concentration were identical with those observed in spontaneous ovulatory cycles with or without conception.

摘要

26名因不育前来咨询的患者接受了人绝经期促性腺激素-人绒毛膜促性腺激素（HMG-HCG）疗程治疗。通过每日评估血浆17β-雌二醇浓度来监测卵巢成熟情况。一旦17β-雌二醇水平达到250 pg/ml，即给予HCG。在第一组7名缺乏雌激素活性的闭经患者中，妊娠率为71.4%，排卵率为91.7%。在第二组5名有雌激素活性证据的闭经患者中，妊娠率为80.0%，排卵率为100%。在第三组14名月经过少的患者中，妊娠率达到71.4%，排卵率为96.9%。总体妊娠率为73.0%。采用通过血浆17β-雌二醇水平监测HMG-HCG治疗的这一方法，多胎妊娠率仅为11.7%，仅观察到1例轻度卵巢过度刺激病例。排卵前和受孕前的17β-雌二醇浓度与在有或无受孕的自然排卵周期中观察到的浓度相同。