Notation A D, Tagatz G E, Steffes M W
Obstet Gynecol. 1978 Feb;51(2):204-9.
Thirteen patients with hypogonadotropic hypogonadism were treated with human menopausal gonadotropins (hMG) and human chorionic gonadotropin (hCG) to induce ovulation. Daily serum 17beta-estradiol (E2) assays were used to monitor the ovarian response to HMG. Apparent ovulation, documented by basal body temperatures, occurred in 41 of 53 hMG-hCG treatment cycles. Thirteen pregnancies occurred in 8 of the 13 patients. One twin pregnancy resulted. The hyperstimulation syndrome did not occur. Our data indicate that an optimal pregnancy rate with a minimum risk of hyperstimulation can be achieved when ovulation is induced 24 hours after the preovulatory serum E2 concentration has reached 500 to 900 pg/ml. Ovulation is induced by administering 10,000 IU and 5000 IU hCG on successive days. In addition, we now routinely give two or three injections of 2500 IU hCG at subsequent 3- to 4-day intervals to support the corpus luteum.
13例低促性腺激素性性腺功能减退患者接受了人绝经期促性腺激素（hMG）和人绒毛膜促性腺激素（hCG）治疗以诱导排卵。每日检测血清17β-雌二醇（E2）以监测卵巢对hMG的反应。根据基础体温记录，53个hMG-hCG治疗周期中有41个出现明显排卵。13例患者中的8例发生了13次妊娠。其中1例为双胎妊娠。未发生卵巢过度刺激综合征。我们的数据表明，当排卵前血清E2浓度达到500至900 pg/ml后24小时诱导排卵时，可实现最佳妊娠率且卵巢过度刺激风险最小。通过连续两天分别注射10,000 IU和5000 IU hCG来诱导排卵。此外，我们现在常规在随后的3至4天间隔给予两到三次2500 IU hCG注射以支持黄体功能。
