Miura K, Kanazawa M, Watanabe K, Doi T, Miyahara T, Hino K, Niwa H
Dept. of Int. Med. II, National Defense Medical College.
Gan No Rinsho. 1989 Nov;35(14):1693-8.
A 51-year-old male sought a medical advice because of gastric lesion that had been detected by a mass screening though the man felt no symptoms. Gastrofiberscopy revealed a superficially elevated, depressed lesion on the lesser curvature of the antrum. Biopsy specimens showed a moderately differentiated adenocarcinoma, and surgically obtained material, about 1.5 cm in diameter, revealed a carcinoid and tubular adenocarcinoma. The tumor consisted mainly of carcinoid tissue while the surface of the tumor manifested, histologically, an adenocarcinoma, though the margins of the two histologies were unclear. The carcinoid tissue revealed a positive Grimerius-staining and a negative Fontana-Silver staining. Fifteen patients having a gastric lesion containing a carcinoid and a carcinoma have been reported in Japan. Five of these 15 cases were pointed out as having existing transient features between the cancer and carcinoid.
一名51岁男性因在大规模筛查中发现胃部病变前来就医，尽管他并无任何症状。胃镜检查显示胃窦小弯处有一个浅表隆起、凹陷性病变。活检标本显示为中分化腺癌，手术切除的直径约1.5厘米的标本显示为类癌和管状腺癌。肿瘤主要由类癌组织构成，而肿瘤表面在组织学上表现为腺癌，不过两种组织学类型的边界并不清晰。类癌组织 Grimelius 染色呈阳性，Fontana-Silver 染色呈阴性。在日本，已有15例报告显示胃部病变同时包含类癌和癌。这15例中的5例被指出在癌症和类癌之间存在过渡特征。
