Zhou Chuankun, Wang Huan, Zou Yinshuang, Fang Huang
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015 Nov;29(11):1441-5.
To review the recent progress in research on the role of estrogen and estrogen receptor on the onset and progression of adolescent idiopathic scoliosis (AIS).
The recently published clinical and experimental literature at home and abroad on abnormality of estrogen and its receptor in AIS was reviewed and summarized.
There are many abnormal changes of estrogen and estrogen receptor in most AIS patients, including higher serum estrogen concentration, unusual cellular response to estrogen, late age at menarche, and gene polymorphisms of estrogen receptor, which are closely associated with AIS predisposition, curve severity, and scoliosis progression.
Estrogen and its receptor participate in the onset and progression of AIS by certain mechanisms, but exact mechanism remains indefinite, which needs further research to better define the role of estrogen and its receptor in AIS.
综述雌激素及其受体在青少年特发性脊柱侧凸（AIS）发病及进展中作用的研究进展。
回顾并总结国内外近期发表的关于AIS中雌激素及其受体异常的临床和实验文献。
多数AIS患者存在雌激素及其受体的多种异常变化，包括血清雌激素浓度升高、细胞对雌激素反应异常、初潮年龄延迟以及雌激素受体基因多态性，这些均与AIS易感性、侧弯严重程度及脊柱侧凸进展密切相关。
雌激素及其受体通过某些机制参与AIS的发病及进展，但确切机制尚不清楚，需要进一步研究以更好地明确雌激素及其受体在AIS中的作用。
