青少年特发性脊柱侧凸的病因：文献综述
Etiology of Adolescent Idiopathic Scoliosis: A Literature Review.
作者信息
Kikanloo Sina Rashidi, Tarpada Sandip Parshottam, Cho Woojin
机构信息
Department of Orthopedic Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
出版信息
Asian Spine J. 2019 Jun;13(3):519-526. doi: 10.31616/asj.2018.0096. Epub 2019 Feb 13.
Abstract
Adolescent idiopathic scoliosis (AIS) is the peripubertal development of spinal curvature of a minimum of 10°. AIS is thought to be attributable to genetic factors, nutrition, early exposure to toxins, and hormonal dysregulation. Recent literature suggests these factors may compound to determine both disease onset and severity. Currently, treatment is limited to observation, bracing, and surgical intervention. Intervention is presently determined by severity and risk of curve progression. As they emerge, new therapies may target specific etiologies of AIS.
摘要
青少年特发性脊柱侧凸（AIS）是指在青春期发育阶段脊柱出现至少10°的弯曲。AIS被认为可归因于遗传因素、营养状况、早期接触毒素以及激素失调。最近的文献表明，这些因素可能共同作用，决定疾病的发病和严重程度。目前，治疗方法仅限于观察、支具治疗和手术干预。目前，干预措施是根据侧弯严重程度和进展风险来确定的。随着新疗法的出现，它们可能针对AIS的特定病因。
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Sci Rep. 2017 Jun 9;7(1):3173. doi: 10.1038/s41598-017-03310-x.
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Volumetric and Fatty Infiltration Imbalance of Deep Paravertebral Muscles in Adolescent Idiopathic Scoliosis.青少年特发性脊柱侧弯患者椎旁深层肌肉的体积及脂肪浸润失衡
Med Sci Monit. 2017 May 2;23:2089-2095. doi: 10.12659/msm.902455.
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Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis.全基因组关联研究确定了新的易感基因座，并突出了Wnt/β-连环蛋白通路在青少年特发性脊柱侧凸发展中的作用。
Hum Mol Genet. 2017 Apr 15;26(8):1577-1583. doi: 10.1093/hmg/ddx045.
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Mol Med Rep. 2016 Dec;14(6):5719-5724. doi: 10.3892/mmr.2016.5927. Epub 2016 Nov 7.
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