Keşkek Şakir Özgür, Sağlıker Yahya, Kırım Sinan, İçen Yahya Kemal, Yıldırım Arafat
Department of Internal Medicine, Numune Training and Research Hospital.
J Nutr Sci Vitaminol (Tokyo). 2015;61(6):460-4. doi: 10.3177/jnsv.61.460.
Hypophosphatemia has been found to be associated with multiple organ dysfunction. In this study we aimed to investigate the association between low serum phosphorus and acute heart failure. A total of 213 subjects, 101 patients with acute heart failure and 112 healthy subjects were included in this case-control study. Serum phosphorus levels, calcium levels, and PTH concentrations were measured. Ejection fraction percentages, pulse rates, systolic and diastolic blood pressures were recorded. The groups were similar in terms of age and gender (p=0.067 and 0.995, respectively). The phosphorus levels and ejection fraction percentages of the patients with heart failure were lower than for the healthy subjects (p<0.001). Frequency of hypophosphatemia was higher in the heart failure group (p<0.001). There was a strong relationship between low serum phosphorus level and acute heart failure (OR 9.85, CI 95% 3.6-26.3, p<0.001). The phosphorus level of patients with acute heart failure was found to be low in this study. Therefore, the phosphorus level should be controlled in patients with acute heart failure and phosphorus supplementation can be a complimentary treatment for these patients.
低磷血症已被发现与多器官功能障碍有关。在本研究中，我们旨在调查低血清磷与急性心力衰竭之间的关联。本病例对照研究共纳入213名受试者，其中101例急性心力衰竭患者和112名健康受试者。测量了血清磷水平、钙水平和甲状旁腺激素浓度。记录了射血分数百分比、脉搏率、收缩压和舒张压。两组在年龄和性别方面相似（p分别为0.067和0.995）。心力衰竭患者的磷水平和射血分数百分比低于健康受试者（p<0.001）。心力衰竭组低磷血症的发生率更高（p<0.001）。血清磷水平低与急性心力衰竭之间存在密切关系（OR 9.85，95%CI 3.6-26.3，p<0.001）。本研究发现急性心力衰竭患者的磷水平较低。因此，应控制急性心力衰竭患者的磷水平，补充磷可作为这些患者的辅助治疗方法。
