Valvere V Iu, Shkhvatsabaia L V, Niu-Tian-de G B
Kardiologiia. 1989 Sep;29(9):64-7.
Thirty patients with Grade III breast cancer, a locally common form, were examined to compare the magnitude of the cardiotoxic effects displayed by the antitumor anthracyclic antibiotics adriamycin (15 patients) and pharmorubicin (15 patients). Clinical symptoms of cardiotoxicity developed in 13.3% of the pharmorubicin-treated and in 40% of the adriamycin-treated patients. Among the noninvasive techniques, electrocardiography turned out to be more informative, which enabled the signs of myocardial dystrophy and cardiac arrhythmias to be identified in 20 and 40% on pharmorubicin and adriamycin, respectively. Poly- and echocardiography proved to be less informative than it was shown by the data available in the literature, which is associated with the use of relatively small total doses of anthracycline in our investigations.
对30例III级乳腺癌（一种局部常见类型）患者进行了检查，以比较抗肿瘤蒽环类抗生素阿霉素（15例患者）和表柔比星（15例患者）所表现出的心脏毒性作用的程度。表柔比星治疗的患者中13.3%出现了心脏毒性的临床症状，阿霉素治疗的患者中这一比例为40%。在非侵入性技术中，心电图结果显示信息量更大，在接受表柔比星和阿霉素治疗的患者中，分别有20%和40%的患者可通过心电图识别出心肌营养不良和心律失常的迹象。心脏超声和超声心动图的信息量比文献数据显示的要少，这与我们研究中使用的蒽环类药物总剂量相对较小有关。
