Lee Sea-Won, Kang Keon Wook, Wu Hong-Gyun
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
Head Neck. 2016 Apr;38 Suppl 1:E1746-55. doi: 10.1002/hed.24310. Epub 2016 Feb 15.
The purpose of this study was to prospectively evaluate the scintigraphic results on patients who undergo intensity-modulated radiotherapy (IMRT) to investigate the tolerance doses for the salivary glands.
Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy (RT), and then at 6 weeks and again at 3 months after the completion of RT. Xerostomia was recorded according to the Radiation Therapy and Oncology Group (RTOG) grade. Salivary function was evaluated by calculating the excretion rate changes (ΔF) for each salivary gland before and after RT.
The parotid mean dose was significantly related to parotid ΔF and the submandibular gland mean dose to the submandibular gland ΔF. The parotid mean dose of 23 Gy was best correlated with the RTOG grades. The submandibular gland mean dose significantly related to ΔF ≤-50% and ≤-75% was 42 Gy.
The parotid mean dose of 23 Gy and the submandibular gland mean dose of 42 Gy is feasible for salivary function preservation in the IMRT era. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1746-E1755, 2016.
本研究旨在前瞻性评估接受调强放疗（IMRT）患者的闪烁扫描结果，以研究唾液腺的耐受剂量。
对35例头颈部癌患者在放疗（RT）开始前进行唾液闪烁扫描，然后在放疗结束后6周和3个月时再次进行扫描。根据放射治疗肿瘤学组（RTOG）分级记录口干情况。通过计算放疗前后各唾液腺的排泄率变化（ΔF）来评估唾液功能。
腮腺平均剂量与腮腺ΔF显著相关，下颌下腺平均剂量与下颌下腺ΔF显著相关。腮腺平均剂量23 Gy与RTOG分级相关性最佳。与ΔF≤ -50%和≤ -75%显著相关的下颌下腺平均剂量为42 Gy。
在IMRT时代，腮腺平均剂量23 Gy和下颌下腺平均剂量42 Gy对保留唾液功能是可行的。© 2016威利期刊公司。《头颈》38: E1746 - E1755, 2016。
