Division of Dermatology, Wexner Medical Center at Ohio State University, Gahanna, OH, 43440, U.S.A.
The Ohio State University College of Medicine, Columbus, OH, U.S.A.
Br J Dermatol. 2016 Oct;175(4):782-4. doi: 10.1111/bjd.14484. Epub 2016 Jun 10.
Graft-versus-host disease-associated angiomatosis (GVHD-AA) is an uncommon manifestation of chronic GVHD consisting of friable vascular proliferations. Using fluorescence in situ hybridization, we demonstrate the presence of donor-derived endothelial cells within areas of GVHD-AA. This is the first documented occurrence of a benign neoplastic growth in relationship to a form of chronic GVHD.
移植物抗宿主病相关性血管病(GVHD-AA)是慢性移植物抗宿主病的一种罕见表现,由易碎的血管增生组成。通过荧光原位杂交,我们在 GVHD-AA 区域内发现了供体来源的内皮细胞。这是首例与慢性移植物抗宿主病相关的良性肿瘤生长的记录。