通过钯催化与氨基催化相结合的连续多催化过程构建对映体富集的多取代六氢哒嗪。
Construction of enantioenriched polysubstituted hexahydropyridazines via a sequential multicatalytic process merging palladium catalysis and aminocatalysis.
作者信息
Marques A-S, Giardinetti M, Marrot J, Coeffard V, Moreau X, Greck C
机构信息
Institut Lavoisier Versailles, UMR CNRS 8180, Université de Versailles-St-Quentin-en-Yvelines, 45 Avenue des États-Unis, 78035 Versailles cedex, France.
出版信息
Org Biomol Chem. 2016 Mar 14;14(10):2828-32. doi: 10.1039/c5ob02437d.
PMID:26876217
Abstract
An efficient multicatalytic strategy for the construction of nitrogen-containing heterocycles has been reported. The powerful combination of organic and metal catalysis in a single vessel allowed the formation of enantioenriched polysubstituted cyclic 6-membered hydrazines bearing a quaternary stereocenter in good yields and selectivities.
摘要
据报道，一种用于构建含氮杂环的高效多催化策略。有机催化与金属催化在单一反应容器中的有效结合，使得能够以良好的产率和选择性形成带有季碳立体中心的对映体富集多取代环状六元肼。
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