通过钯催化的串联偶联/环异构化过程，从 1,6-烯炔高效构建五元芳香族和非芳香族杂环。

Efficient construction of five-membered aromatic and nonaromatic heterocycles from 1,6-enynes by a palladium-catalyzed domino coupling/cycloisomerization process.

机构信息

Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Institute of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.

出版信息

J Org Chem. 2010 Feb 5;75(3):582-8. doi: 10.1021/jo9020776.

DOI:10.1021/jo9020776

PMID:20030303

Abstract

General and efficient methods for the construction of five-membered aromatic and nonaromatic heterocycles by palladium-catalyzed coupling/cycloisomerization of 1,6-enynes and aryl halides have been developed. Results indicate that substituents at the terminus of the alkynes have a significant effect on the selective formation of the products.

摘要

开发了钯催化的 1,6-烯炔和芳基卤化物偶联/环异构化构建五员芳香族和非芳香族杂环的通用高效方法。结果表明，炔烃末端取代基对产物的选择性形成有显著影响。