Xu Junqing, Xu Zefeng, Wang Jingya, Li Bing, Sun Xiujuan, Qin Tiejun, Zhang Yue, Zhang Hongli, Fang Liwei, Pan Lijuan, Hu Naibo, Qu Shiqiang, Xiao Zhijian
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC. The State Key Laboratory of Experimental Hematology, Tianjin 300020, China.
Zhonghua Xue Ye Xue Za Zhi. 2016 Jan;37(1):26-9. doi: 10.3760/cma.j.issn.0253-2727.2016.01.005.
To investigate the value of myeloproliferative neoplasms Symptom Assessment Form total symptom score (MPN-SAF-TSS)in assessing constitutional symptoms among Ph/BCR- ABL negative myeloproliferative neoplasm (MPN)patients.
A cohort of 628 MPN patients were evaluated by MPN- SAF- TSS.
Fatigue was the most common symptom (76.0%, 76.2%vs 89.9%)and the highest average severity of all the symptoms (3.46±2.97, 3.47±2.99vs 4.74±3.04 scores)among polycythemia vera (PV), essential thrombocythemia (ET)and primary myelofibrosis (PMF)patients. Using the MPN- SAF- TSS analysis, PMF patients showed highest burden of symptoms (28.9 ± 19.1), followed by PV patients (19.2 ± 16.8), and finally ET patients (17.1 ± 15.3). Instinct differences were observed between PMF and PV patients (χ(2)=6.371,P=0.021), PMF and ET patients (χ(2)= 14.020,P<0.001). No significant difference was found between PV and ET patients (χ(2)=2.281,P=0.191).
MPN- SAF- TSS was effective in evaluating the symptomatic burden among Ph/BCRABL negative MPN patients and could be used for serial assessment in this clinical setting.
探讨骨髓增殖性肿瘤症状评估表总症状评分（MPN-SAF-TSS）在评估Ph/BCR-ABL阴性骨髓增殖性肿瘤（MPN）患者全身症状中的价值。
采用MPN-SAF-TSS对628例MPN患者进行评估。
在真性红细胞增多症（PV）、原发性血小板增多症（ET）和原发性骨髓纤维化（PMF）患者中，疲劳是最常见的症状（分别为76.0%、76.2%和89.9%），且是所有症状中平均严重程度最高的（评分分别为3.46±2.97、3.47±2.99和4.74±3.04）。通过MPN-SAF-TSS分析，PMF患者的症状负担最高（28.9±19.1），其次是PV患者（19.2±16.8），最后是ET患者（17.1±15.3）。PMF与PV患者之间（χ(2)=6.371，P=0.021）、PMF与ET患者之间（χ(2)= 14.020，P<0.001）存在显著差异。PV与ET患者之间无显著差异（χ(2)=2.281，P=0.191）。
MPN-SAF-TSS可有效评估Ph/BCR-ABL阴性MPN患者的症状负担，并可用于该临床环境中的系列评估。
