[Ph/BCR-ABL阴性骨髓增殖性肿瘤患者的症状负担评估]

[The assessment of symptomatic burden among Ph/BCR- ABL negative myeloproliferative neoplasm patients].

作者信息

Xu Junqing, Xu Zefeng, Wang Jingya, Li Bing, Sun Xiujuan, Qin Tiejun, Zhang Yue, Zhang Hongli, Fang Liwei, Pan Lijuan, Hu Naibo, Qu Shiqiang, Xiao Zhijian

机构信息

Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC. The State Key Laboratory of Experimental Hematology, Tianjin 300020, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2016 Jan;37(1):26-9. doi: 10.3760/cma.j.issn.0253-2727.2016.01.005.

DOI:10.3760/cma.j.issn.0253-2727.2016.01.005

PMID:26876249

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7342297/

Abstract

OBJECTIVE

To investigate the value of myeloproliferative neoplasms Symptom Assessment Form total symptom score (MPN-SAF-TSS)in assessing constitutional symptoms among Ph/BCR- ABL negative myeloproliferative neoplasm (MPN)patients.

METHODS

A cohort of 628 MPN patients were evaluated by MPN- SAF- TSS.

RESULTS

Fatigue was the most common symptom (76.0%, 76.2%vs 89.9%)and the highest average severity of all the symptoms (3.46±2.97, 3.47±2.99vs 4.74±3.04 scores)among polycythemia vera (PV), essential thrombocythemia (ET)and primary myelofibrosis (PMF)patients. Using the MPN- SAF- TSS analysis, PMF patients showed highest burden of symptoms (28.9 ± 19.1), followed by PV patients (19.2 ± 16.8), and finally ET patients (17.1 ± 15.3). Instinct differences were observed between PMF and PV patients (χ(2)=6.371,P=0.021), PMF and ET patients (χ(2)= 14.020,P<0.001). No significant difference was found between PV and ET patients (χ(2)=2.281,P=0.191).

CONCLUSION

MPN- SAF- TSS was effective in evaluating the symptomatic burden among Ph/BCRABL negative MPN patients and could be used for serial assessment in this clinical setting.

摘要

目的

探讨骨髓增殖性肿瘤症状评估表总症状评分（MPN-SAF-TSS）在评估Ph/BCR-ABL阴性骨髓增殖性肿瘤（MPN）患者全身症状中的价值。

方法

采用MPN-SAF-TSS对628例MPN患者进行评估。

结果

在真性红细胞增多症（PV）、原发性血小板增多症（ET）和原发性骨髓纤维化（PMF）患者中，疲劳是最常见的症状（分别为76.0%、76.2%和89.9%），且是所有症状中平均严重程度最高的（评分分别为3.46±2.97、3.47±2.99和4.74±3.04）。通过MPN-SAF-TSS分析，PMF患者的症状负担最高（28.9±19.1），其次是PV患者（19.2±16.8），最后是ET患者（17.1±15.3）。PMF与PV患者之间（χ(2)=6.371，P=0.021）、PMF与ET患者之间（χ(2)= 14.020，P<0.001）存在显著差异。PV与ET患者之间无显著差异（χ(2)=2.281，P=0.191）。