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[Acute promyelocytic leukemia with stat5b- RARα fusiongene: a case report and literatures review].

作者信息

Liu Lirong, Chen Suning, Tan Junfeng, Shi Pengfei, Chen Kuang, Gao Daquan, Huang Xilian, Xie Yaping, Xu Ying, Yang Fan, Qian Shenxian

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2016 Jan;37(1):68-9. doi: 10.3760/cma.j.issn.0253-2727.2016.01.014.

DOI:10.3760/cma.j.issn.0253-2727.2016.01.014
PMID:26876258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7342306/
Abstract
摘要

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[Acute promyelocytic leukemia with stat5b- RARα fusiongene: a case report and literatures review].[伴有Stat5b-RARα融合基因的急性早幼粒细胞白血病：1例报告及文献复习]
Zhonghua Xue Ye Xue Za Zhi. 2016 Jan;37(1):68-9. doi: 10.3760/cma.j.issn.0253-2727.2016.01.014.
2
Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.新型急性早幼粒细胞白血病融合蛋白STAT5b-RARα与维甲酸受体及STAT3信号通路的相互作用
Blood. 2002 Apr 15;99(8):2637-46. doi: 10.1182/blood.v99.8.2637.
3
Acute promyelocytic leukemia with a STAT5b-RARα fusion transcript defined by array-CGH, FISH, and RT-PCR.通过阵列比较基因组杂交、荧光原位杂交和逆转录聚合酶链反应确定具有STAT5b-RARα融合转录本的急性早幼粒细胞白血病。
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4
All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.具有变异型STAT5B-RARA融合基因的急性早幼粒细胞白血病对全反式维甲酸和三氧化二砷的耐药性
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Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations.急性早幼粒细胞白血病：变异易位的综述与讨论
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Acute promyelocytic leukemia and variant fusion proteins: PLZF-RARα fusion protein at a glance.急性早幼粒细胞白血病和变异融合蛋白：PLZF-RARα 融合蛋白一览。
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The theory of APL.急性早幼粒细胞白血病的理论
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Translocations of the RARalpha gene in acute promyelocytic leukemia.急性早幼粒细胞白血病中RARalpha基因的易位
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The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.Stat5-RARα融合蛋白通过与共抑制复合物相互作用来抑制转录和分化。
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Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.转基因小鼠中不同的白血病表型以及早幼粒细胞白血病变异融合基因PLZF-RARα和NPM-RARα产生的不同共抑制因子相互作用。
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6318-23. doi: 10.1073/pnas.96.11.6318.

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Treatment of a STAT5b::RARα positive case of APL in a patient not eligible for intensive chemotherapy.一名不符合强化化疗条件的急性早幼粒细胞白血病（APL）患者中STAT5b::RARα阳性病例的治疗
Ir J Med Sci. 2024 Dec;193(6):2875-2881. doi: 10.1007/s11845-024-03751-0. Epub 2024 Jul 20.
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Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review.伴有STAT5B/RARa融合基因的急性早幼粒细胞白血病患者对地西他滨反应良好吗？：一例病例报告及文献综述
Medicine (Baltimore). 2020 Oct 23;99(43):e22923. doi: 10.1097/MD.0000000000022923.
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Characterization of atypical acute promyelocytic leukaemia: Three cases report and literature review.非典型急性早幼粒细胞白血病的特征：三例报告及文献复习
Medicine (Baltimore). 2019 May;98(19):e15537. doi: 10.1097/MD.0000000000015537.

本文引用的文献

1
All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.具有变异型STAT5B-RARA融合基因的急性早幼粒细胞白血病对全反式维甲酸和三氧化二砷的耐药性
Leukemia. 2013 Jul;27(7):1606-10. doi: 10.1038/leu.2012.371. Epub 2012 Dec 28.
2
Acute promyelocytic leukemia with a STAT5b-RARα fusion transcript defined by array-CGH, FISH, and RT-PCR.通过阵列比较基因组杂交、荧光原位杂交和逆转录聚合酶链反应确定具有STAT5b-RARα融合转录本的急性早幼粒细胞白血病。
Cancer Genet. 2012 Jun;205(6):327-31. doi: 10.1016/j.cancergen.2012.02.007.
3
Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia.开发实时定量聚合酶链反应检测方法，以跟踪治疗抵抗性急性早幼粒细胞白血病的反应。
Front Oncol. 2011 Oct 25;1:35. doi: 10.3389/fonc.2011.00035. eCollection 2011.
4
Identification of the STAT5B-RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPα mutation.在一名急性早幼粒细胞白血病患者中鉴定出 STAT5B-RARα 融合转录本，该患者无 FLT3、NPM1、c-Kit 和 C/EBPα 突变。
Eur J Haematol. 2011 May;86(5):442-6. doi: 10.1111/j.1600-0609.2011.01595.x. Epub 2011 Mar 30.
5
Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA.急性早幼粒细胞白血病，其STAT5B-RARA中存在STAT5B-RARA融合基因以及STAT5B SH2结构域中的G596V错义突变。
Eur J Haematol. 2009 Nov;83(5):499-501. doi: 10.1111/j.1600-0609.2009.01324.x. Epub 2009 Jul 18.
6
Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.在G显带染色体17正常的急性早幼粒细胞白血病中检测STAT5B-RARA融合转录本
Eur J Haematol. 2008 May;80(5):444-7. doi: 10.1111/j.1600-0609.2008.01042.x. Epub 2008 Jan 23.
7
The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease.急性早幼粒细胞白血病的分子发病机制：对该疾病临床管理的启示
Blood Rev. 2003 Jun;17(2):71-97. doi: 10.1016/s0268-960x(02)00075-9.
8
The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia.
Hum Mol Genet. 1999 Sep;8(9):1741-9. doi: 10.1093/hmg/8.9.1741.