英国一家大型儿科医院中轮状病毒疫苗的早期影响
Early impact of rotavirus vaccination in a large paediatric hospital in the UK.
作者信息
Hungerford D, Read J M, Cooke R P D, Vivancos R, Iturriza-Gómara M, Allen D J, French N, Cunliffe N
机构信息
Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Field Epidemiology Services, Public Health England, Liverpool, UK.
CHICAS Group, Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
出版信息
J Hosp Infect. 2016 Jun;93(2):117-20. doi: 10.1016/j.jhin.2015.12.010. Epub 2015 Dec 31.
The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
在英国一家大型儿童医院，研究了13年期间常规轮状病毒疫苗接种对社区获得性（CA）和医疗保健相关（HA）轮状病毒胃肠炎（RVGE）的影响。2002年7月至2015年6月期间，共有1644名0至15岁的住院儿童轮状病毒检测呈阳性。中断时间序列分析表明，在引入疫苗后（2013年7月至2015年6月），CA-RVGE和HA-RVGE住院率分别比预期低83%[95%置信区间（CI）：72-90%]和83%（95%CI：66-92%）。轮状病毒疫苗接种迅速降低了CA-RVGE和HA-RVGE病例中医院轮状病毒疾病负担。
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