Yamashita Toru, Abe Koji
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Neurol Med Chir (Tokyo). 2016;56(3):97-101. doi: 10.2176/nmc.ra.2015-0309. Epub 2016 Feb 15.
The discovery of induced pluripotent stem (iPS) cells opened the gate for reprogramming technology with which we can change the cell fate through overexpression of master transcriptional factors. Now we can prepare various kinds of neuronal cells directly induced from somatic cells. It has been reported that overexpression of a neuron-specific transcriptional factors might change the cell fate of endogenous astroglia to neuronal cells in vivo. In addition, some research groups demonstrated that chemical compound can induce chemical-induced neuronal cells, without transcriptional factors overexpression. In this review, we briefly review recent progress in the induced neuronal (iN) cells, and discuss the possibility of application for cell transplantation therapy.
诱导多能干细胞（iPS细胞）的发现为重新编程技术打开了大门，通过该技术我们可以通过过表达主要转录因子来改变细胞命运。现在我们可以直接从体细胞制备各种神经元细胞。据报道，神经元特异性转录因子的过表达可能会在体内将内源性星形胶质细胞的细胞命运改变为神经元细胞。此外，一些研究小组表明，化合物可以在不过表达转录因子的情况下诱导化学诱导的神经元细胞。在这篇综述中，我们简要回顾了诱导神经元（iN）细胞的最新进展，并讨论了其在细胞移植治疗中的应用可能性。
