Social regulation of adult neurogenesis: A comparative approach.

The social environment sculpts the mammalian brain throughout life. Adult neurogenesis, the birth of new neurons in the mature brain, can be up- or down-regulated by various social manipulations. These include social isolation, social conflict, social status, socio-sexual interactions, and parent/offspring interactions. However, socially-mediated changes in neuron production are often species-, sex-, and/or region-specific. In order to reconcile the variability of social effects on neurogenesis, we need to consider species-specific social adaptations and other contextual variables (e.g. age, social status, reproductive status, etc.) that shift the valence of social stimuli. Using a comparative approach to understand how adult-generated neurons in turn influence social behaviors will shed light on how adult neurogenesis contributes to survival and reproduction in diverse species.