成熟哺乳动物脑外伤后内源性神经源性细胞反应。
Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.
作者信息
Sun Dong
机构信息
Department of Neurosurgery, Virginia Commonwealth University, P.O. Box 980631, Medical College of Virginia Campus, Richmond, VA 23298-631, USA.
出版信息
Exp Neurol. 2016 Jan;275 Pt 3(0 3):405-410. doi: 10.1016/j.expneurol.2015.04.017. Epub 2015 Apr 30.
Abstract
In the mature mammalian brain, new neurons are generated throughout life in the neurogenic regions of the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus. Over the past two decades, extensive studies have examined the extent of adult neurogenesis in the SVZ and DG, the role of the adult generated new neurons in normal brain function and the underlying mechanisms regulating the process of adult neurogenesis. The extent and the function of adult neurogenesis under neuropathological conditions have also been explored in varying types of disease models in animals. Increasing evidence has indicated that these endogenous neural stem/progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. This review will discuss the potential functions of adult neurogenesis in the injured brain and will describe the recent development of strategies aimed at harnessing this neurogenic capacity in order to repopulate and repair the injured brain following trauma.
摘要
在成熟的哺乳动物大脑中，终生都会在脑室下区（SVZ）和海马齿状回（DG）这些神经发生区域产生新的神经元。在过去二十年中，广泛的研究探讨了SVZ和DG中成年神经发生的程度、成年产生的新神经元在正常脑功能中的作用以及调节成年神经发生过程的潜在机制。在各种动物疾病模型中，也研究了神经病理条件下成年神经发生的程度和功能。越来越多的证据表明，这些内源性神经干细胞/祖细胞在应对中枢神经系统损伤或疾病时可能发挥再生和修复作用。本综述将讨论成年神经发生在受损大脑中的潜在功能，并描述旨在利用这种神经发生能力以在创伤后重新填充和修复受损大脑的策略的最新进展。
相似文献
1
Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.成熟哺乳动物脑外伤后内源性神经源性细胞反应。
Exp Neurol. 2016 Jan;275 Pt 3(0 3):405-410. doi: 10.1016/j.expneurol.2015.04.017. Epub 2015 Apr 30.
3
The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell.多面性的脑室下区星形胶质细胞：从代谢和促神经发生作用到作为神经干细胞发挥作用。
Neuroscience. 2016 May 26;323:20-8. doi: 10.1016/j.neuroscience.2015.10.053. Epub 2015 Nov 3.
4
The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury.内源性神经发生在创伤性脑损伤后的脑修复和再生中的潜力。
Neural Regen Res. 2014 Apr 1;9(7):688-92. doi: 10.4103/1673-5374.131567.
5
Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury.碱性成纤维细胞生长因子增强的神经发生有助于创伤性脑损伤大鼠的认知恢复。
Exp Neurol. 2009 Mar;216(1):56-65. doi: 10.1016/j.expneurol.2008.11.011. Epub 2008 Nov 27.
7
Strategies targeting endogenous neurogenic cell response to improve recovery following traumatic brain injury.针对内源性神经源性细胞反应以改善创伤性脑损伤后恢复的策略。
Brain Res. 2016 Jun 1;1640(Pt A):104-113. doi: 10.1016/j.brainres.2016.01.055. Epub 2016 Feb 8.
8
Effects and Potential Mechanisms of Alcohol Use Disorder on the Fate Determination of Newly Born Neurons in the Hippocampus.酒精使用障碍对海马新生神经元命运决定的影响及其潜在机制。
Alcohol Alcohol. 2020 Oct 20;55(6):598-602. doi: 10.1093/alcalc/agaa083.
9
Survivin, a key component of the Wnt/β-catenin signaling pathway, contributes to traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus.Survivin，Wnt/β-catenin 信号通路的关键组成部分，有助于小鼠齿状回创伤性脑损伤诱导的成年神经发生。
Int J Mol Med. 2013 Oct;32(4):867-75. doi: 10.3892/ijmm.2013.1456. Epub 2013 Jul 24.
10
The subventricular zone in the immature piglet brain: anatomy and exodus of neuroblasts into white matter after traumatic brain injury.未成熟仔猪脑室内下区：创伤性脑损伤后神经母细胞的解剖结构及向白质的迁出
Dev Neurosci. 2015;37(2):115-30. doi: 10.1159/000369091. Epub 2015 Feb 10.
引用本文的文献
1
Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury.生物材料以及基于干细胞/外泌体的策略在创伤性脑损伤治疗中的研究进展。
Acta Pharm Sin B. 2025 Jul;15(7):3511-3544. doi: 10.1016/j.apsb.2025.05.010. Epub 2025 May 21.
2
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice.愈合蓝图：斑马鱼和新生小鼠的中枢神经系统再生
BMC Biol. 2025 Apr 30;23(1):115. doi: 10.1186/s12915-025-02203-0.
3
Effect of Electromagnetic Field on Proliferation and Migration of Fibroblasts and Keratinocytes: Implications in Wound Healing and Regeneration.电磁场对成纤维细胞和角质形成细胞增殖与迁移的影响：对伤口愈合和再生的意义
J Biotechnol Biomed. 2024;7(3):387-399. doi: 10.26502/jbb.2642-91280162. Epub 2024 Sep 4.
4
Dendritic morphological development of traumatic brain injury-induced new neurons in the dentate gyrus is important for post-injury cognitive recovery and is regulated by Notch1.创伤性脑损伤诱导的齿状回新生神经元的树突形态发育对于损伤后认知恢复很重要，并且受 Notch1 调节。
Exp Neurol. 2024 Dec;382:114963. doi: 10.1016/j.expneurol.2024.114963. Epub 2024 Sep 18.
5
Porous Three-Dimensional Polyurethane Scaffolds Promote Scar-Free Endogenous Regeneration After Acute Brain Hemorrhage.多孔三维聚氨酯支架促进急性脑出血后无瘢痕内源性再生。
Transl Stroke Res. 2025 Apr;16(2):299-314. doi: 10.1007/s12975-023-01212-x. Epub 2023 Nov 23.
6
Single-nucleus transcriptomic mapping of blast-induced traumatic brain injury in mice hippocampus.单细胞转录组图谱分析小鼠海马体中爆炸诱导性创伤性脑损伤。
Sci Data. 2023 Sep 20;10(1):638. doi: 10.1038/s41597-023-02552-x.
7
The Adult Neurogenesis Theory of Alzheimer's Disease.阿尔茨海默病的成人神经发生理论。
J Alzheimers Dis. 2023;93(4):1237-1276. doi: 10.3233/JAD-221279.
8
NDRG2 regulates the formation of reactive astrocyte-derived progenitor cells Notch signaling pathway after brain traumatic injury in rats.NDRG2调节大鼠脑外伤后反应性星形胶质细胞衍生的祖细胞Notch信号通路的形成。
Front Mol Neurosci. 2023 Apr 4;16:1149683. doi: 10.3389/fnmol.2023.1149683. eCollection 2023.
9
Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?神经发生龛中细胞对神经元死亡的迁移反应：和谐修复的开始？
Int J Mol Sci. 2023 Apr 1;24(7):6587. doi: 10.3390/ijms24076587.
10
Traumatic brain injury: Mechanisms, manifestations, and visual sequelae.创伤性脑损伤：机制、表现及视觉后遗症。
Front Neurosci. 2023 Feb 23;17:1090672. doi: 10.3389/fnins.2023.1090672. eCollection 2023.
本文引用的文献
1
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.异常的海马神经发生会导致癫痫及相关认知功能衰退。
Nat Commun. 2015 Mar 26;6:6606. doi: 10.1038/ncomms7606.
2
The subventricular zone in the immature piglet brain: anatomy and exodus of neuroblasts into white matter after traumatic brain injury.未成熟仔猪脑室内下区：创伤性脑损伤后神经母细胞的解剖结构及向白质的迁出
Dev Neurosci. 2015;37(2):115-30. doi: 10.1159/000369091. Epub 2015 Feb 10.
3
Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice.经颅低强度激光疗法可增强小鼠创伤性脑损伤后的学习、记忆及神经祖细胞功能。
J Biomed Opt. 2014;19(10):108003. doi: 10.1117/1.JBO.19.10.108003.
4
Regulation and function of adult neurogenesis: from genes to cognition.成体神经发生的调控与功能：从基因到认知
Physiol Rev. 2014 Oct;94(4):991-1026. doi: 10.1152/physrev.00004.2014.
5
Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury.一种神经营养肽对轻至中度创伤性脑损伤神经发生和记忆的增强作用。
Neurosurgery. 2015 Feb;76(2):201-14; discussion 214-5. doi: 10.1227/NEU.0000000000000577.
6
Inhibition of injury-induced cell proliferation in the dentate gyrus of the hippocampus impairs spontaneous cognitive recovery after traumatic brain injury.抑制海马齿状回中损伤诱导的细胞增殖会损害创伤性脑损伤后的自发认知恢复。
J Neurotrauma. 2015 Apr 1;32(7):495-505. doi: 10.1089/neu.2014.3545. Epub 2015 Jan 22.
7
Adult newborn neurons are involved in learning acquisition and long-term memory formation: the distinct demands on temporal neurogenesis of different cognitive tasks.成年新生神经元参与学习获得和长期记忆形成：不同认知任务对时间性神经发生的独特需求。
Hippocampus. 2015 Jan;25(1):51-61. doi: 10.1002/hipo.22349. Epub 2014 Sep 25.
8
Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury.胰岛素样生长因子-1的条件性过表达可增强海马神经发生，并在创伤性脑损伤后恢复未成熟神经元的树突状突起。
J Neuropathol Exp Neurol. 2014 Aug;73(8):734-46. doi: 10.1097/NEN.0000000000000092.
9
Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury.血管紧张素受体 2 型激活可诱导创伤性脑损伤后的神经保护和神经发生。
Neurotherapeutics. 2014 Jul;11(3):665-78. doi: 10.1007/s13311-014-0286-x.
10
The functional significance of newly born neurons integrated into olfactory bulb circuits.新生神经元整合到嗅球回路中的功能意义。
Front Neurosci. 2014 May 26;8:121. doi: 10.3389/fnins.2014.00121. eCollection 2014.
Zotero 插件