Hettema John M
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Psychophysiology. 2016 Mar;53(3):348-50. doi: 10.1111/psyp.12550.
Two articles in this issue seek to further the goal of NIMH's Research Domain Criteria (RDoC) initiative to develop new approaches for investigating mental disorders, using fundamental dimensions that cut across traditional disorder categories and align more closely with mechanisms that underlie psychopathology. One article, by Lang, McTeague, and Bradley, describes the construction of such a disorder cross-crossing dimension of fear response. The other, by Kozak and Cuthbert, expounds upon the basis and conceptualization of research targets under RDoC. Possible implications of these developments for psychiatric genetics research are discussed.
本期的两篇文章旨在推进美国国立精神卫生研究所（NIMH）的研究领域标准（RDoC）计划的目标，即开发研究精神障碍的新方法，使用跨越传统障碍类别的基本维度，并更紧密地与精神病理学的潜在机制保持一致。一篇由朗、麦克蒂格和布拉德利撰写的文章，描述了这种恐惧反应的跨障碍维度的构建。另一篇由科扎克和卡斯伯特撰写的文章，阐述了RDoC下研究目标的基础和概念化。还讨论了这些进展对精神疾病遗传学研究可能产生的影响。
