Department of Psychology, University of Wisconsin-Madison.
Waisman Center, University of Wisconsin-Madison.
J Psychopathol Clin Sci. 2022 Aug;131(6):626-640. doi: 10.1037/abn0000652.
We use the highly structured Laboratory-Temperament Assessment Battery to measure behaviors that map onto the Research Domain Criteria (RDoC) positive and negative valence systems. Using a birth record-based sample (N = 1374 individual twins; mean age 7.7 years), we created composites of observed behavior reflecting the RDoC constructs Reward Responsiveness, Frustrative Nonreward, Loss, and Fear. Next, we related the RDoC constructs concurrently and longitudinally to problem behaviors, measured using parent-report on the Health Behavior Questionnaire and symptom counts from the Diagnostic Interview Schedule for Children, Version IV (DISC-IV; reflecting DSM-IV). The four pediatric RDoC positive and negative valence system measures, especially Reward Responsiveness, Frustrative Nonreward, and Loss, were heritable and modestly but plausibly related to traditional DSM-based measures in a transdiagnostic manner. The modest predictions from RDoC measures to DSM-based measures were largely genetically mediated, although relationships with aggressive and oppositional behaviors were also influenced by common environmental factors. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
我们使用高度结构化的实验室-气质评估电池来测量与研究领域标准（RDoC）正性和负性效价系统相对应的行为。使用基于出生记录的样本（N=1374 对个体双胞胎；平均年龄 7.7 岁），我们创建了反映 RDoC 结构奖赏反应性、挫败性非奖赏、损失和恐惧的观察行为的综合指标。接下来，我们使用父母报告的健康行为问卷和儿童诊断访谈量表第四版（DISC-IV；反映 DSM-IV）的症状计数，同时和纵向地将 RDoC 结构与问题行为相关联。这四个儿科 RDoC 正性和负性效价系统测量指标，特别是奖赏反应性、挫败性非奖赏和损失，具有遗传性，并且以跨诊断的方式与传统的基于 DSM 的测量指标有适度但合理的关联。RDoC 测量指标对基于 DSM 的测量指标的适度预测在很大程度上是由遗传因素介导的，尽管与攻击和对立行为的关系也受到共同环境因素的影响。（PsycInfo 数据库记录（c）2022 APA，保留所有权利）。
