Rademaker B, Raber J
Department of Pharmacology, Duphar BV, Weesp, The Netherlands.
Pharm Weekbl Sci. 1989 Oct 20;11(5):137-45. doi: 10.1007/BF01959460.
Several diseases can, at least in theory, be treated by the administration of an enzyme, the deficiency of which is the cause of the disease. Various attempts have been made to correct enzymatic deficiencies responsible for the clinical manifestation of diseases for which prevention cannot be achieved by modification of the diet or by supportive therapy with drugs. Except for treating certain digestive disorders, enzyme-replacement therapy has not yet found a broad application. In this review article a compilation is given of the problems and prospects of enzyme-replacement therapy in diseases caused by the deficiency of an enzyme.
至少在理论上，有几种疾病可以通过给予一种酶来治疗，而该酶的缺乏正是导致这些疾病的原因。人们已经进行了各种尝试，以纠正那些导致疾病临床表现的酶缺乏症，而这些疾病无法通过调整饮食或药物支持疗法来预防。除了治疗某些消化系统疾病外，酶替代疗法尚未得到广泛应用。在这篇综述文章中，我们总结了酶替代疗法在由酶缺乏引起的疾病中的问题和前景。
