Timmerman H
Department of Pharmacochemistry, Faculty of Chemistry, Free University, Amsterdam, The Netherlands.
Pharm Weekbl Sci. 1989 Oct 20;11(5):146-50. doi: 10.1007/BF01959461.
The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions, as well as on specific ligands, both agonists and antagonists. It is concluded that several aspects of the pharmacology of histamine in the central nervous system are still a matter of empirism and speculations. The recent publications on the brain-penetrating H2 antagonist zolantidine and the selective H3 agonists and antagonists are expected to contribute to the knowledge of the histaminergic pathways in the brain. Therapeutical areas within the central nervous system are related to behaviour (including wake-sleep), neuroendocrinal processes, the control of muscle activity and cerebral circulation.
本文讨论了组胺在脑功能中的作用。简要回顾了三种组胺受体的生物化学和功能，以及特定的配体，包括激动剂和拮抗剂。得出的结论是，组胺在中枢神经系统中的药理学的几个方面仍然是经验主义和推测的问题。关于脑穿透性H2拮抗剂佐兰替丁以及选择性H3激动剂和拮抗剂的最新出版物有望增进对脑中组胺能途径的了解。中枢神经系统内的治疗领域与行为（包括觉醒-睡眠）、神经内分泌过程、肌肉活动控制和脑循环有关。
